Aripiprazole and Sertraline Interaction
Drug interaction information between Aripiprazole and Sertraline.
Aripiprazole and Sertraline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Aripiprazole and Sertraline. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Aripiprazole does not interfere with the way your body handles sertraline.
What To Do
You can safely take these medications together without needing to change your dosage.
FDA Label Information
Additionally, no dosage adjustment is necessary for valproate, lithium, lamotrigine, lorazepam, or sertraline when co-administered with aripiprazole [see Clinical Pharmacology (12.3)] .
Aripiprazole Also Interacts With
- Omeprazole minor
- Escitalopram minor
- Fluoxetine minor
- Famotidine minor
- Venlafaxine minor
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
Frequently Asked Questions
Can I take Aripiprazole and Sertraline together?
This is a minor interaction. You can safely take these medications together without needing to change your dosage.
How serious is the interaction between Aripiprazole and Sertraline?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Aripiprazole and Sertraline interact?
Aripiprazole does not interfere with the way your body handles sertraline.
Understanding the Aripiprazole and Sertraline Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Aripiprazole belongs to the Atypical Antipsychotic class and Sertraline belongs to the Selective Serotonin Reuptake Inhibitor (SSRI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Aripiprazole does not interfere with the way your body handles sertraline. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Aripiprazole has 19 total documented interactions on file in this dataset, and Sertraline has 34. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You can safely take these medications together without needing to change your dosage. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Aripiprazole or Sertraline based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.