Aripiprazole and Sertraline Interaction
Drug interaction information between Aripiprazole and Sertraline.
Aripiprazole and Sertraline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Aripiprazole and Sertraline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aripiprazole does not interfere with the way your body handles sertraline.
FDA Label Information
Additionally, no dosage adjustment is necessary for valproate, lithium, lamotrigine, lorazepam, or sertraline when co-administered with aripiprazole [see Clinical Pharmacology (12.3)] .
Aripiprazole Also Interacts With
- Omeprazole minor
- Escitalopram minor
- Fluoxetine minor
- Famotidine minor
- Venlafaxine minor
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
Frequently Asked Questions
What SPL severity band is on file for Aripiprazole + Sertraline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sertraline has 34 labeled pairs on file vs Aripiprazole's 19. In the minor band specifically: Aripiprazole has 19 (also Omeprazole, Escitalopram, Fluoxetine, Famotidine); Sertraline has 31 (also Fluoxetine, Citalopram, Paroxetine, Atenolol).
What mechanism field is on file for Aripiprazole and Sertraline?
Aripiprazole does not interfere with the way your body handles sertraline.
Sertraline carries more major-labeled pairs than Aripiprazole
SPL source-record counts only. This page's band is minor · classes on file: Aripiprazole (Atypical Antipsychotic); Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)).
Sertraline has 1 major-labeled pair vs Aripiprazole's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Aripiprazole
- Omeprazole
- Escitalopram
- Fluoxetine
- Famotidine
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Fluoxetine
- Citalopram
- Paroxetine
- Atenolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.