Olanzapine and Warfarin Interaction
Drug interaction information between Olanzapine and Warfarin.
Olanzapine and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Olanzapine and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not interfere with how the body processes or removes each other. They are generally safe to take together without changing the dose.
FDA Label Information
Warfarin — Warfarin (20 mg single dose) did not affect olanzapine pharmacokinetics [see Drug Interactions ( 7.2 )] . Warfarin — Single doses of olanzapine did not affect the pharmacokinetics of warfarin [see Drug Interactions ( 7.1 )] .
Olanzapine Also Interacts With
- Fluoxetine major
- Tetrabenazine moderate
- Omeprazole minor
- Diazepam minor
- Carbamazepine minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Olanzapine + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Olanzapine's 26. In the minor band specifically: Olanzapine has 24 (also Omeprazole, Diazepam, Carbamazepine, Lithium); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Olanzapine and Warfarin?
These two drugs do not interfere with how the body processes or removes each other. They are generally safe to take together without changing the dose.
Warfarin carries more major-labeled pairs than Olanzapine
SPL source-record counts only. This page's band is minor · classes on file: Olanzapine (Atypical Antipsychotic); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Olanzapine's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 24 minor · 26 total
- Other minor peers for Olanzapine
- Omeprazole
- Diazepam
- Carbamazepine
- Lithium
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.