olanzapine vs warfarin
Side-by-side comparison of olanzapine and warfarin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Warfarin — Warfarin (20 mg single dose) did not affect olanzapine pharmacokinetics [see Drug Interactions ( 7.2 )] . Warfarin — Single doses of olanzapine did not affect the pharmacokinetics of warfarin [see Drug Interactions ( 7.1 )] .
Recommendation: No specific dose changes are needed, but continue to follow your doctor's regular monitoring plan.
Zyprexa
Coumadin, Jantoven
Olanzapine is a medicine used to treat certain mental disorders. It helps to balance chemicals in the brain to improve mood and behavior.
Warfarin is a medicine that helps prevent blood clots. It is used to treat and prevent dangerous clots from forming in your body.
Olanzapine is used to treat schizophrenia in adults and teens (13-17). It also treats manic or mixed episodes of bipolar I disorder in adults and teens (13-17). In adults, it can be used with other medicines to treat bipolar depression.
Warfarin is used to prevent and treat blood clots in your veins and lungs. It can also prevent clots if you have atrial fibrillation (irregular heartbeat) or a replacement heart valve. After a heart attack, it can lower the risk of death, another heart attack, or a stroke.
Olanzapine is an atypical antipsychotic. It works by affecting the levels of certain chemicals in your brain. These chemicals include dopamine and serotonin, which can help improve mood, thinking, and behavior.
Warfarin works by blocking your body's use of vitamin K. Vitamin K is needed to make blood clotting factors. By blocking vitamin K, warfarin makes your blood less likely to clot.
- • Dizziness
- • Weight gain
- • Increased appetite
- • Dry mouth
- • Constipation
- • Bleeding from any tissue or organ
- Weight gain 6,721
- Diabetes 5,388
- The medicine is interacting with another medicine 4,050
- Poisoning from different substances 3,965
- Sleepiness 3,838
- INR increased 10,275
- Shortness of breath 8,408
- Interaction with another medicine 6,289
- Tiredness 6,141
- Feeling sick to your stomach 5,921
Olanzapine can increase the risk of death in older adults with dementia-related psychosis. Olanzapine is not approved to treat this condition. When using olanzapine with fluoxetine, read the Symbyax label for more warnings.
Warfarin can cause major or fatal bleeding. You must have your blood tested regularly (INR) while taking warfarin. Many things, like other medicines and diet changes, can affect your INR. Tell your doctor about any bleeding and follow their instructions to prevent bleeding.
If you take olanzapine during the third trimester of pregnancy, your baby may have withdrawal symptoms after birth. There is a pregnancy registry to monitor outcomes in women who take atypical antipsychotics during pregnancy. Talk to your doctor.
Warfarin can harm your unborn baby, especially during the first three months of pregnancy. Do not take warfarin if you are pregnant, unless you have a mechanical heart valve and your doctor says the benefits outweigh the risks. Talk to your doctor if you are breastfeeding, and watch your baby for bruising or bleeding.
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How to Read This olanzapine vs warfarin Comparison
olanzapine is classified in the Atypical Antipsychotic drug class, while warfarin sits within the Vitamin K Antagonist (Anticoagulant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, olanzapine has 23,962 submissions while warfarin has 37,034. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these two drugs do not interfere with how the body processes or removes each other. they are generally safe to take together without changing the dose.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between olanzapine and warfarin - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.