Olanzapine and Diazepam Interaction
Drug interaction information between Olanzapine and Diazepam.
Olanzapine and Diazepam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Olanzapine and Diazepam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medicines together can cause a sudden drop in blood pressure when you stand up. This can lead to dizziness or fainting.
FDA Label Information
Diazepam: May potentiate orthostatic hypotension. ( 7.2 ) 7.1 Potential for Other Drugs to Affect Olanzapine Diazepam — The co-administration of diazepam with olanzapine potentiated the orthostatic hypotension observed with olanzapine [see Drug Interactions ( 7.2 )] . Diazepam — Olanzapine did not influence the pharmacokinetics of diazepam or its active metabolite N-desmethyldiazepam.
Olanzapine Also Interacts With
- Fluoxetine major
- Tetrabenazine moderate
- Omeprazole minor
- Warfarin minor
- Carbamazepine minor
Diazepam Also Interacts With
- Clonazepam moderate
- Fluoxetine moderate
- Mirtazapine moderate
- Raloxifene moderate
- Omeprazole minor
Frequently Asked Questions
What SPL severity band is on file for Olanzapine + Diazepam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Olanzapine and Diazepam tie at 26 labeled pairs each. minor-band counts: Olanzapine 24 alongside Omeprazole, Warfarin, Carbamazepine, Lithium; Diazepam 22 alongside Omeprazole, Ketoconazole, Fluvoxamine, Cimetidine.
What mechanism field is on file for Olanzapine and Diazepam?
Taking these medicines together can cause a sudden drop in blood pressure when you stand up. This can lead to dizziness or fainting.
Olanzapine carries more major-labeled pairs than Diazepam
SPL source-record counts only. This page's band is minor · classes on file: Olanzapine (Atypical Antipsychotic); Diazepam (Benzodiazepine).
Olanzapine has 1 major-labeled pair vs Diazepam's 0. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 24 minor · 26 total
- Other minor peers for Olanzapine
- Omeprazole
- Warfarin
- Carbamazepine
- Lithium
0 major · 4 moderate · 22 minor · 26 total
- Other minor peers for Diazepam
- Omeprazole
- Ketoconazole
- Fluvoxamine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.