What the FDA labels say about taking them together
Olanzapine and omeprazole
Olanzapine's FDA label of March 5, 2026 names omeprazole in its drug interactions section; the omeprazole labels PlainMeds reads (2) do not name olanzapine. The olanzapine label: “Inducers of CYP1A2 or Glucuronyl Transferase – Omeprazole and rifampin may cause an increase in olanzapine clearance.”
Check it at the source: the olanzapine FDA label on DailyMed (effective March 5, 2026, Macleods Pharmaceuticals Limited); the omeprazole FDA label on DailyMed (effective April 22, 2024, Apotex Corp).
What does the olanzapine label say about omeprazole?
Olanzapine label, drug interactionsInducers of CYP1A2 or Glucuronyl Transferase – Omeprazole and rifampin may cause an increase in olanzapine clearance.
Source: FDA drug label (Zyprexa Relprevv, NDA022173), H2-Pharma LLC, effective May 19, 2026 (SPL set 11544cba-64a9-49cb-8d74-da228053b252), via openFDA
Source: FDA drug label (Olanzapine), Macleods Pharmaceuticals Limited, effective March 5, 2026 (SPL set 8e095987-bdea-42f2-9550-c7155cf07d30), via openFDA; the full label on DailyMed
What does the omeprazole label say about olanzapine?
Omeprazole's label (effective April 22, 2024) and its 1 other brand-application label do not name olanzapine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Omeprazole), Apotex Corp, effective April 22, 2024 (SPL set b83329ac-a65e-b3af-a3fb-c5a6c740e5e7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Olanzapine | Omeprazole | |
|---|---|---|
| Labeled for | Schizophrenia, Bipolar disorder, Depression | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.147 per tablet 20 mg tablet | $0.0295 per capsule 20 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once