Olanzapine and Omeprazole Interaction
Drug interaction information between Olanzapine and Omeprazole.
Olanzapine and Omeprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Olanzapine and Omeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Omeprazole makes the body get rid of olanzapine faster than normal. This could make the olanzapine less effective because there is not enough of it in your system.
FDA Label Information
Inducers of CYP1A2 or Glucuronyl Transferase — Omeprazole and rifampin may cause an increase in olanzapine clearance.
Olanzapine Also Interacts With
- Fluoxetine major
- Tetrabenazine moderate
- Warfarin minor
- Diazepam minor
- Carbamazepine minor
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Frequently Asked Questions
What SPL severity band is on file for Olanzapine + Omeprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Omeprazole has 27 labeled pairs on file vs Olanzapine's 26. In the minor band specifically: Olanzapine has 24 (also Warfarin, Diazepam, Carbamazepine, Lithium); Omeprazole has 22 (also Aripiprazole, Atomoxetine, Brexpiprazole, Carbamazepine).
What mechanism field is on file for Olanzapine and Omeprazole?
Omeprazole makes the body get rid of olanzapine faster than normal. This could make the olanzapine less effective because there is not enough of it in your system.
Omeprazole's labeled portfolio outnumbers Olanzapine
SPL source-record counts only. This page's band is minor · classes on file: Olanzapine (Atypical Antipsychotic); Omeprazole (Proton Pump Inhibitor (PPI)).
1 major · 1 moderate · 24 minor · 26 total
- Other minor peers for Olanzapine
- Warfarin
- Diazepam
- Carbamazepine
- Lithium
1 major · 4 moderate · 22 minor · 27 total
- Other minor peers for Omeprazole
- Aripiprazole
- Atomoxetine
- Brexpiprazole
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.