Norethindrone and Atorvastatin Interaction
Drug interaction information between Norethindrone and Atorvastatin.
Norethindrone and Atorvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Norethindrone and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking atorvastatin can raise the levels of this hormone in your bloodstream.
FDA Label Information
Oral Contraceptives: May increase plasma levels of norethindrone and ethinyl estradiol; consider this effect when selecting an oral contraceptive (7.3 ). Table 4: Atorvastatin Effects on Other Drugs Oral Contraceptives Clinical Impact: Co-administration of atorvastatin and an oral contraceptive increased plasma concentrations of norethindrone and ethinyl estradiol [see Clinical Pharmacology (12.3) ].
Norethindrone Also Interacts With
- Voriconazole major
- Colchicine minor
- Colesevelam minor
- Darunavir minor
- Fluconazole minor
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Norethindrone + Atorvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Atorvastatin has 36 labeled pairs on file vs Norethindrone's 10. In the minor band specifically: Norethindrone has 9 (also Colchicine, Colesevelam, Darunavir, Fluconazole); Atorvastatin has 25 (also Estradiol, Ketoconazole, Erythromycin, Rifampin).
What mechanism field is on file for Norethindrone and Atorvastatin?
Taking atorvastatin can raise the levels of this hormone in your bloodstream.
Atorvastatin carries more major-labeled pairs than Norethindrone
SPL source-record counts only. This page's band is minor · classes on file: Norethindrone (Progestin-Only Oral Contraceptive); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Atorvastatin has 3 major-labeled pairs vs Norethindrone's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 9 minor · 10 total
- Other minor peers for Norethindrone
- Colchicine
- Colesevelam
- Darunavir
- Fluconazole
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Ketoconazole
- Erythromycin
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.