Norethindrone and Fluconazole Interaction
Drug interaction information between Norethindrone and Fluconazole.
Norethindrone and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Norethindrone and Fluconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Fluconazole causes a slight increase in the amount of birth control hormones that stay in your bloodstream.
What To Do
These drugs can be taken together, but you should tell your doctor if you notice any new symptoms.
FDA Label Information
A third study evaluated the potential interaction of once-weekly dosing of fluconazole 300 mg to 21 normal females taking an oral contraceptive containing ethinyl estradiol and norethindrone. In this placebo-controlled, double-blind, randomized, two-way crossover study carried out over three cycles of oral contraceptive treatment, fluconazole dosing resulted in small increases in the mean AUCs of ethinyl estradiol and norethindrone compared to similar placebo dosing. The mean AUCs of ethinyl estradiol and norethindrone increased by 24% (95% C.I.
Norethindrone Also Interacts With
- Voriconazole major
- Atorvastatin minor
- Colchicine minor
- Colesevelam minor
- Darunavir minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
Can I take Norethindrone and Fluconazole together?
This is a minor interaction. These drugs can be taken together, but you should tell your doctor if you notice any new symptoms.
How serious is the interaction between Norethindrone and Fluconazole?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Norethindrone and Fluconazole interact?
Fluconazole causes a slight increase in the amount of birth control hormones that stay in your bloodstream.
Understanding the Norethindrone and Fluconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Norethindrone belongs to the Progestin-Only Oral Contraceptive class and Fluconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Fluconazole causes a slight increase in the amount of birth control hormones that stay in your bloodstream. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Norethindrone has 10 total documented interactions on file in this dataset, and Fluconazole has 67. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: These drugs can be taken together, but you should tell your doctor if you notice any new symptoms. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Norethindrone or Fluconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.