Norethindrone and Fluconazole Interaction
Drug interaction information between Norethindrone and Fluconazole.
Norethindrone and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Norethindrone and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole causes a slight increase in the amount of birth control hormones that stay in your bloodstream.
FDA Label Information
A third study evaluated the potential interaction of once-weekly dosing of fluconazole 300 mg to 21 normal females taking an oral contraceptive containing ethinyl estradiol and norethindrone. In this placebo-controlled, double-blind, randomized, two-way crossover study carried out over three cycles of oral contraceptive treatment, fluconazole dosing resulted in small increases in the mean AUCs of ethinyl estradiol and norethindrone compared to similar placebo dosing. The mean AUCs of ethinyl estradiol and norethindrone increased by 24% (95% C.I.
Norethindrone Also Interacts With
- Voriconazole major
- Atorvastatin minor
- Colchicine minor
- Colesevelam minor
- Darunavir minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Norethindrone + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Norethindrone's 10. In the minor band specifically: Norethindrone has 9 (also Atorvastatin, Colchicine, Colesevelam, Darunavir); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Norethindrone and Fluconazole?
Fluconazole causes a slight increase in the amount of birth control hormones that stay in your bloodstream.
Fluconazole carries more major-labeled pairs than Norethindrone
SPL source-record counts only. This page's band is minor · classes on file: Norethindrone (Progestin-Only Oral Contraceptive); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Norethindrone's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 9 minor · 10 total
- Other minor peers for Norethindrone
- Atorvastatin
- Colchicine
- Colesevelam
- Darunavir
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.