Norethindrone and Voriconazole Interaction
Drug interaction information between Norethindrone and Voriconazole.
Norethindrone and Voriconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Norethindrone and Voriconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole slows down the process your body uses to get rid of the birth control pill. This can lead to higher levels of the birth control in your blood and increase your risk of side effects.
FDA Label Information
John's Wort (CYP450 inducer; P-gp inducer) Significantly Reduced Contraindicated Oral Contraceptives containing ethinyl estradiol and norethindrone (CYP2C19 Inhibition) Increased Monitoring for adverse reactions and toxicity related to voriconazole is recommended when coadministered with oral contraceptives. Oral Contraceptives containing ethinyl estradiol and norethindrone (CYP3A4 Inhibition) Increased Monitoring for adverse reactions related to oral contraceptives is recommended during coadministration.
Norethindrone Also Interacts With
- Atorvastatin minor
- Colchicine minor
- Colesevelam minor
- Darunavir minor
- Fluconazole minor
Voriconazole Also Interacts With
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
- Phenytoin major
Frequently Asked Questions
What SPL severity band is on file for Norethindrone + Voriconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Norethindrone's 10. In the major band specifically: Norethindrone has 1; Voriconazole has 8 (also Rifampin, Lurasidone, Pimozide, Ivabradine).
What mechanism field is on file for Norethindrone and Voriconazole?
Voriconazole slows down the process your body uses to get rid of the birth control pill. This can lead to higher levels of the birth control in your blood and increase your risk of side effects.
Voriconazole carries more major-labeled pairs than Norethindrone
SPL source-record counts only. This page's band is major · classes on file: Norethindrone (Progestin-Only Oral Contraceptive); Voriconazole (Azole Antifungal).
Voriconazole has 8 major-labeled pairs vs Norethindrone's 1.
1 major · 0 moderate · 9 minor · 10 total
Norethindrone has no other major-band peer in this dataset besides Voriconazole.
8 major · 9 moderate · 33 minor · 50 total
- Other major peers for Voriconazole
- Rifampin
- Lurasidone
- Pimozide
- Ivabradine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.