Propranolol and Verapamil Interaction
Drug interaction information between Propranolol and Verapamil.
Propranolol and Verapamil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Propranolol and Verapamil. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These drugs both slow the heart and relax blood vessels. Using them together can cause a dangerously slow heart rate or heart failure.
What To Do
Your doctor must monitor you very closely if you take both. Tell your doctor immediately if you feel very tired or dizzy.
FDA Label Information
There have been reports of significant bradycardia, heart failure, and cardiovascular collapse with concurrent use of verapamil and beta-blockers.
Propranolol Also Interacts With
- Clonidine minor
- Diltiazem minor
- Warfarin minor
- Doxazosin minor
- Haloperidol minor
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
Can I take Propranolol and Verapamil together?
This is a minor interaction. Your doctor must monitor you very closely if you take both. Tell your doctor immediately if you feel very tired or dizzy.
How serious is the interaction between Propranolol and Verapamil?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Propranolol and Verapamil interact?
These drugs both slow the heart and relax blood vessels. Using them together can cause a dangerously slow heart rate or heart failure.
Understanding the Propranolol and Verapamil Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Propranolol belongs to the Non-Selective Beta-Blocker class and Verapamil belongs to the Calcium Channel Blocker class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These drugs both slow the heart and relax blood vessels. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Propranolol has 44 total documented interactions on file in this dataset, and Verapamil has 57. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor must monitor you very closely if you take both. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Propranolol or Verapamil based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.