What the FDA labels say about taking them together
Propranolol and verapamil
Propranolol's FDA label of January 15, 2026 names verapamil in its drug interactions section, and verapamil's label names propranolol too. The verapamil label: “A decrease in metoprolol and propranolol clearance has been observed when either drug is administered concomitantly with verapamil.”
Check it at the source: the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.); the verapamil FDA label on DailyMed (effective April 6, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the propranolol label say about verapamil?
Propranolol label, drug interactionsThere have been reports of significant bradycardia, heart failure, and cardiovascular collapse with concurrent use of verapamil and beta-blockers.
Inderal Xl label (ANI Pharmaceuticals, Inc., August 27, 2026), warnings and precautionsThe concomitant use of beta-adrenergic blockers and non-dihydropyridine calcium channel blockers (e.g., verapamil and diltiazem), digoxin or clonidine increases the risk of significant bradycardia.
Source: FDA drug label (Inderal Xl, NDA021438), ANI Pharmaceuticals, Inc., effective August 27, 2026 (SPL set ac196ff5-9215-402b-bc57-69aa87f8bade), via openFDA
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
What does the verapamil label say about propranolol?
Verapamil label, drug interactionsA decrease in metoprolol and propranolol clearance has been observed when either drug is administered concomitantly with verapamil.
Verapamil label, warningsPatients with hypertrophic cardiomyopathy (IHSS): In 120 patients with hypertrophic cardiomyopathy (most of them refractory or intolerant to propranolol) who received therapy with verapamil at doses up to 720 mg/day, a variety of serious adverse effects were seen.
Verapamil Hydrochloride label (EXELA PHARMA SCIENCES, LLC, February 21, 2017), contraindicationsPatients receiving intravenous beta-adrenergic blocking drugs (e.g., propranolol).
Source: FDA drug label (Verapamil Hydrochloride, NDA018925), EXELA PHARMA SCIENCES, LLC, effective February 21, 2017 (SPL set eff5e83b-f819-4a5b-9746-12bce328d7a7), via openFDA
Source: FDA drug label (Verapamil Hydrochloride, NDA020943), Wilshire Pharmaceuticals, Inc., effective November 27, 2024 (SPL set 5f665d08-e1e4-422a-88c2-d8834abf9e1a), via openFDA
Source: FDA drug label (Verapamil hydrochloride), Zydus Pharmaceuticals (USA) Inc., effective April 6, 2026 (SPL set e19ab8d8-dae5-489d-9805-7e7407bea06d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Propranolol | Verapamil | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Atrial fibrillation, Migraine | High blood pressure, Atrial fibrillation, Angina |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0493 per tablet 20 mg tablet | $0.191 per tablet 180 mg tablet |
| Shortage now | In shortage | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once