Propranolol and Verapamil Interaction
Drug interaction information between Propranolol and Verapamil.
Propranolol and Verapamil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Propranolol and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both slow the heart and relax blood vessels. Using them together can cause a dangerously slow heart rate or heart failure.
FDA Label Information
There have been reports of significant bradycardia, heart failure, and cardiovascular collapse with concurrent use of verapamil and beta-blockers.
Propranolol Also Interacts With
- Clonidine minor
- Diltiazem minor
- Warfarin minor
- Doxazosin minor
- Haloperidol minor
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Propranolol + Verapamil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Propranolol's 44. In the minor band specifically: Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Doxazosin); Verapamil has 47 (also Atorvastatin, Aspirin, Atenolol, Timolol).
What mechanism field is on file for Propranolol and Verapamil?
These drugs both slow the heart and relax blood vessels. Using them together can cause a dangerously slow heart rate or heart failure.
Verapamil carries more major-labeled pairs than Propranolol
SPL source-record counts only. This page's band is minor · classes on file: Propranolol (Non-Selective Beta-Blocker); Verapamil (Calcium Channel Blocker).
Verapamil has 4 major-labeled pairs vs Propranolol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 44 minor · 44 total
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Atenolol
- Timolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.