Propranolol and Warfarin Interaction
Drug interaction information between Propranolol and Warfarin.
Propranolol and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Propranolol and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Propranolol increases the amount of warfarin in your blood. This makes the blood thinner and increases your risk of bleeding.
FDA Label Information
Warfarin Propranolol when administered with warfarin increases the concentration of warfarin.
Propranolol Also Interacts With
- Clonidine minor
- Diltiazem minor
- Verapamil minor
- Doxazosin minor
- Haloperidol minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Propranolol + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Propranolol's 44. In the minor band specifically: Propranolol has 44 (also Clonidine, Diltiazem, Verapamil, Doxazosin); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Propranolol and Warfarin?
Propranolol increases the amount of warfarin in your blood. This makes the blood thinner and increases your risk of bleeding.
Warfarin carries more major-labeled pairs than Propranolol
SPL source-record counts only. This page's band is minor · classes on file: Propranolol (Non-Selective Beta-Blocker); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Propranolol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 44 minor · 44 total
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.