Propranolol and Clonidine Interaction
Drug interaction information between Propranolol and Clonidine.
Propranolol and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Propranolol and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Propranolol can work against clonidine and stop it from lowering your blood pressure. This can cause blood pressure to rise, especially if you stop taking clonidine.
FDA Label Information
The antihypertensive effects of clonidine may be antagonized by beta-blockers. Propranolol should be administered cautiously to patients withdrawing from clonidine.
Propranolol Also Interacts With
- Diltiazem minor
- Warfarin minor
- Verapamil minor
- Doxazosin minor
- Haloperidol minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Propranolol + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Clonidine's 29. In the minor band specifically: Propranolol has 44 (also Diltiazem, Warfarin, Verapamil, Doxazosin); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol).
What mechanism field is on file for Propranolol and Clonidine?
Propranolol can work against clonidine and stop it from lowering your blood pressure. This can cause blood pressure to rise, especially if you stop taking clonidine.
Propranolol's labeled portfolio outnumbers Clonidine
SPL source-record counts only. This page's band is minor · classes on file: Propranolol (Non-Selective Beta-Blocker); Clonidine (Central Alpha-2 Agonist).
0 major · 0 moderate · 44 minor · 44 total
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.