Metoclopramide and Atropine Interaction
Drug interaction information between Metoclopramide and Atropine.
Metoclopramide and Atropine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metoclopramide and Atropine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Metoclopramide speeds up the stomach and can cancel out the slowing effect that atropine has on digestion.
FDA Label Information
7 DRUG INTERACTIONS 7.1 Mexiletine Atropine Sulfate Injection decreased the rate of mexiletine absorption without altering the relative oral bioavailability; this delay in mexiletine absorption was reversed by the combination of atropine and intravenous metoclopramide during pretreatment for anesthesia.
Metoclopramide Also Interacts With
- Posaconazole major
- Lidocaine Topical moderate
- Rivastigmine moderate
- Tacrolimus Topical moderate
- Tranylcypromine moderate
Atropine Also Interacts With
- Mexiletine minor
- Imipramine minor
- Midazolam minor
- Nabilone minor
- Pramlintide minor
Frequently Asked Questions
What SPL severity band is on file for Metoclopramide + Atropine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metoclopramide has 23 labeled pairs on file vs Atropine's 6. In the minor band specifically: Metoclopramide has 18 (also Acetaminophen, Cyclosporine, Tetracycline, Atovaquone/Proguanil); Atropine has 6 (also Mexiletine, Imipramine, Midazolam, Nabilone).
What mechanism field is on file for Metoclopramide and Atropine?
Metoclopramide speeds up the stomach and can cancel out the slowing effect that atropine has on digestion.
Metoclopramide carries more major-labeled pairs than Atropine
SPL source-record counts only. This page's band is minor · classes on file: Metoclopramide (Prokinetic / Antiemetic); Atropine (Anticholinergic).
Metoclopramide has 1 major-labeled pair vs Atropine's 0. This page itself is in the minor band, not the major band.
1 major · 4 moderate · 18 minor · 23 total
- Other minor peers for Metoclopramide
- Acetaminophen
- Cyclosporine
- Tetracycline
- Atovaquone/Proguanil
0 major · 0 moderate · 6 minor · 6 total
- Other minor peers for Atropine
- Mexiletine
- Imipramine
- Midazolam
- Nabilone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.