Tetracycline and Zinc Sulfate Interaction
Drug interaction information between Tetracycline and Zinc Sulfate.
Tetracycline and Zinc Sulfate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tetracycline and Zinc Sulfate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Zinc can bind to the antibiotic in your stomach and prevent it from being soaked up by your body. This makes the antibiotic less effective at fighting infections.
FDA Label Information
Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium and preparations containing iron, zinc, or sodium bicarbonate.
Tetracycline Also Interacts With
- Theophylline major
- Doxycycline moderate
- Doxycycline Hyclate moderate
- Minocycline moderate
- Atovaquone/Proguanil minor
Zinc Sulfate Also Interacts With
- Baloxavir Marboxil moderate
- Delafloxacin minor
- Levofloxacin minor
- Moxifloxacin minor
Frequently Asked Questions
What SPL severity band is on file for Tetracycline + Zinc Sulfate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tetracycline has 12 labeled pairs on file vs Zinc Sulfate's 5. In the minor band specifically: Tetracycline has 8 (also Atovaquone/Proguanil, Cholestyramine, Colestipol, Dicloxacillin); Zinc Sulfate has 4 (also Delafloxacin, Levofloxacin, Moxifloxacin).
What mechanism field is on file for Tetracycline and Zinc Sulfate?
Zinc can bind to the antibiotic in your stomach and prevent it from being soaked up by your body. This makes the antibiotic less effective at fighting infections.
Tetracycline carries more major-labeled pairs than Zinc Sulfate
SPL source-record counts only. This page's band is minor · classes on file: Tetracycline (Tetracycline Antibiotic); Zinc Sulfate (Mineral Supplement).
Tetracycline has 1 major-labeled pair vs Zinc Sulfate's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 8 minor · 12 total
- Other minor peers for Tetracycline
- Atovaquone/Proguanil
- Cholestyramine
- Colestipol
- Dicloxacillin
0 major · 1 moderate · 4 minor · 5 total
- Other minor peers for Zinc Sulfate
- Delafloxacin
- Levofloxacin
- Moxifloxacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.