Linezolid and Acetaminophen/Oxycodone Interaction
Drug interaction information between Linezolid and Acetaminophen/Oxycodone.
Linezolid and Acetaminophen/Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Linezolid and Acetaminophen/Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs can increase the levels of a chemical called serotonin in your brain, and having too much of it can cause a serious reaction.
FDA Label Information
Serotonergic Drugs The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), tryptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), and monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and...
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Frequently Asked Questions
What SPL severity band is on file for Linezolid + Acetaminophen/Oxycodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Linezolid has 29 labeled pairs on file vs Acetaminophen/Oxycodone's 23. In the minor band specifically: Linezolid has 18 (also Buprenorphine, Buprenorphine/Naloxone, Buprenorphine, Codeine); Acetaminophen/Oxycodone has 21 (also Trazodone, Tramadol, Cyclobenzaprine, Oxycodone).
What mechanism field is on file for Linezolid and Acetaminophen/Oxycodone?
Both of these drugs can increase the levels of a chemical called serotonin in your brain, and having too much of it can cause a serious reaction.
Linezolid carries more major-labeled pairs than Acetaminophen/Oxycodone
SPL source-record counts only. This page's band is minor · classes on file: Linezolid (Oxazolidinone Antibiotic); Acetaminophen/Oxycodone (Opioid Analgesic Combination).
Linezolid has 8 major-labeled pairs vs Acetaminophen/Oxycodone's 0. This page itself is in the minor band, not the major band.
8 major · 3 moderate · 18 minor · 29 total
- Other minor peers for Linezolid
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
- Codeine
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen/Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.