Linezolid and Codeine Interaction
Drug interaction information between Linezolid and Codeine.
Linezolid and Codeine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Linezolid and Codeine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Linezolid can interfere with how your body handles brain chemicals when taken with certain pain medicines. This can lead to a serious condition called serotonin syndrome, which causes fever, confusion, and a rapid heart rate.
FDA Label Information
Examples of these drugs include, selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), and monoamine oxidase (MAO) inhibitors (used to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue) (see PRECAUTIONS; Information for Patients/Caregivers ). Monoamine Oxidase...
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
Codeine Also Interacts With
- Bupropion minor
- Fluoxetine minor
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Frequently Asked Questions
What SPL severity band is on file for Linezolid + Codeine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Linezolid has 29 labeled pairs on file vs Codeine's 27. In the minor band specifically: Linezolid has 18 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Buprenorphine); Codeine has 27 (also Bupropion, Fluoxetine, Trazodone, Tramadol).
What mechanism field is on file for Linezolid and Codeine?
Linezolid can interfere with how your body handles brain chemicals when taken with certain pain medicines. This can lead to a serious condition called serotonin syndrome, which causes fever, confusion, and a rapid heart rate.
Linezolid carries more major-labeled pairs than Codeine
SPL source-record counts only. This page's band is minor · classes on file: Linezolid (Oxazolidinone Antibiotic); Codeine (Opioid Analgesic).
Linezolid has 8 major-labeled pairs vs Codeine's 0. This page itself is in the minor band, not the major band.
8 major · 3 moderate · 18 minor · 29 total
- Other minor peers for Linezolid
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
0 major · 0 moderate · 27 minor · 27 total
- Other minor peers for Codeine
- Bupropion
- Fluoxetine
- Trazodone
- Tramadol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.