Linezolid and Escitalopram Interaction
Drug interaction information between Linezolid and Escitalopram.
Linezolid and Escitalopram have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Linezolid and Escitalopram. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Linezolid acts as a special type of medicine that stops the body from clearing serotonin, which can cause a dangerous reaction when mixed with escitalopram.
FDA Label Information
Intervention: Escitalopram is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [ see Dosage and Administration (2.7) , Contraindications (4) , and Warnings and Precautions (5.2) ] Pimozide Clinical Impact: Concomitant use of racemic citalopram with pimozide increases plasma concentrations of pimozide, a drug with a narrow therapeutic index, and may increase the risk of QT prolongation and/or ventricular arrhythmias compared to use of racemic citalopram alone [ see Clinical Pharmacology (12.3) ].
Linezolid Also Interacts With
- Citalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
- Tranylcypromine major
Escitalopram Also Interacts With
- Citalopram major
- Pimozide major
- Aspirin moderate
- Warfarin moderate
- Buspirone minor
Frequently Asked Questions
What SPL severity band is on file for Linezolid + Escitalopram?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Linezolid has 29 labeled pairs on file vs Escitalopram's 12. In the major band specifically: Linezolid has 8 (also Citalopram, Mirtazapine, Paroxetine, Safinamide); Escitalopram has 3 (also Citalopram, Pimozide).
What mechanism field is on file for Linezolid and Escitalopram?
Linezolid acts as a special type of medicine that stops the body from clearing serotonin, which can cause a dangerous reaction when mixed with escitalopram.
Linezolid carries more major-labeled pairs than Escitalopram
SPL source-record counts only. This page's band is major · classes on file: Linezolid (Oxazolidinone Antibiotic); Escitalopram (Selective Serotonin Reuptake Inhibitor (SSRI)).
Linezolid has 8 major-labeled pairs vs Escitalopram's 3.
8 major · 3 moderate · 18 minor · 29 total
- Other major peers for Linezolid
- Citalopram
- Mirtazapine
- Paroxetine
- Safinamide
3 major · 2 moderate · 7 minor · 12 total
- Other major peers for Escitalopram
- Citalopram
- Pimozide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.