Linezolid and Mirtazapine Interaction
Drug interaction information between Linezolid and Mirtazapine.
Linezolid and Mirtazapine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Linezolid and Mirtazapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Linezolid blocks the breakdown of a brain chemical called serotonin, and adding mirtazapine can cause levels to become dangerously high.
FDA Label Information
Intervention Mirtazapine is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [see Dosage and Administration (2.4) , Contraindications (4) , Warnings and Precautions (5.3) ]. Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact The concomitant use of serotonergic drugs with mirtazapine increases the risk of serotonin syndrome.
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Paroxetine major
- Safinamide major
- Tranylcypromine major
Mirtazapine Also Interacts With
- Alprazolam moderate
- Diazepam moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Frequently Asked Questions
What SPL severity band is on file for Linezolid + Mirtazapine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's major band?
Linezolid and Mirtazapine tie at 29 labeled pairs each. major-band counts: Linezolid 8 alongside Citalopram, Escitalopram, Paroxetine, Safinamide; Mirtazapine 1.
What mechanism field is on file for Linezolid and Mirtazapine?
Linezolid blocks the breakdown of a brain chemical called serotonin, and adding mirtazapine can cause levels to become dangerously high.
Linezolid carries more major-labeled pairs than Mirtazapine
SPL source-record counts only. This page's band is major · classes on file: Linezolid (Oxazolidinone Antibiotic); Mirtazapine (Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)).
Linezolid has 8 major-labeled pairs vs Mirtazapine's 1.
8 major · 3 moderate · 18 minor · 29 total
- Other major peers for Linezolid
- Citalopram
- Escitalopram
- Paroxetine
- Safinamide
1 major · 5 moderate · 23 minor · 29 total
Mirtazapine has no other major-band peer in this dataset besides Linezolid.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.