Linezolid and Buprenorphine/Naloxone Interaction
Drug interaction information between Linezolid and Buprenorphine/Naloxone.
Linezolid and Buprenorphine/Naloxone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Linezolid and Buprenorphine/Naloxone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Linezolid acts as an MAO inhibitor, which can cause a dangerous buildup of serotonin when taken with buprenorphine.
FDA Label Information
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue). Examples: phenelzine, tranylcypromine, linezolid Muscle Relaxants Clinical Impact: Buprenorphine...
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
Buprenorphine/Naloxone Also Interacts With
- Gabapentin minor
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Pregabalin minor
Frequently Asked Questions
What SPL severity band is on file for Linezolid + Buprenorphine/Naloxone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Linezolid has 29 labeled pairs on file vs Buprenorphine/Naloxone's 19. In the minor band specifically: Linezolid has 18 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine, Codeine); Buprenorphine/Naloxone has 19 (also Gabapentin, Trazodone, Tramadol, Cyclobenzaprine).
What mechanism field is on file for Linezolid and Buprenorphine/Naloxone?
Linezolid acts as an MAO inhibitor, which can cause a dangerous buildup of serotonin when taken with buprenorphine.
Linezolid carries more major-labeled pairs than Buprenorphine/Naloxone
SPL source-record counts only. This page's band is minor · classes on file: Linezolid (Oxazolidinone Antibiotic); Buprenorphine/Naloxone (Partial Opioid Agonist / Antagonist).
Linezolid has 8 major-labeled pairs vs Buprenorphine/Naloxone's 0. This page itself is in the minor band, not the major band.
8 major · 3 moderate · 18 minor · 29 total
- Other minor peers for Linezolid
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine
- Codeine
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Buprenorphine/Naloxone
- Gabapentin
- Trazodone
- Tramadol
- Cyclobenzaprine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.