Linezolid and Buprenorphine Interaction
Drug interaction information between Linezolid and Buprenorphine.
Linezolid and Buprenorphine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Linezolid and Buprenorphine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Linezolid is a specific type of medicine that, when combined with buprenorphine, can cause serotonin levels to become dangerously high.
FDA Label Information
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue). Examples: phenelzine, tranylcypromine, linezolid Muscle Relaxants Clinical Impact: Buprenorphine...
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
Buprenorphine Also Interacts With
- Oxycodone moderate
- Trazodone minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Ketoconazole minor
Frequently Asked Questions
What SPL severity band is on file for Linezolid + Buprenorphine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Linezolid and Buprenorphine tie at 29 labeled pairs each. minor-band counts: Linezolid 18 alongside Acetaminophen/Oxycodone, Buprenorphine/Naloxone, Buprenorphine, Codeine; Buprenorphine 28 alongside Trazodone, Cyclobenzaprine, Mirtazapine, Ketoconazole.
What mechanism field is on file for Linezolid and Buprenorphine?
Linezolid is a specific type of medicine that, when combined with buprenorphine, can cause serotonin levels to become dangerously high.
Linezolid carries more major-labeled pairs than Buprenorphine
SPL source-record counts only. This page's band is minor · classes on file: Linezolid (Oxazolidinone Antibiotic); Buprenorphine (Partial Opioid Agonist).
Linezolid has 8 major-labeled pairs vs Buprenorphine's 0. This page itself is in the minor band, not the major band.
8 major · 3 moderate · 18 minor · 29 total
- Other minor peers for Linezolid
- Acetaminophen/Oxycodone
- Buprenorphine/Naloxone
- Buprenorphine
- Codeine
0 major · 1 moderate · 28 minor · 29 total
- Other minor peers for Buprenorphine
- Trazodone
- Cyclobenzaprine
- Mirtazapine
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.