Rosuvastatin and Niacin Interaction
Drug interaction information between Rosuvastatin and Niacin.
Rosuvastatin and Niacin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rosuvastatin and Niacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using high doses of niacin with rosuvastatin can lead to serious muscle damage. Both drugs can affect your muscles, and the combination makes a toxic reaction more likely.
FDA Label Information
Niacin Clinical Impact: Cases of myopathy and rhabdomyolysis have occurred with concomitant use of lipid-modifying doses (≥1 g/day) of niacin with rosuvastatin. Intervention: Consider if the benefit of using lipid-modifying doses (≥1 g/day) of niacin concomitantly with rosuvastatin outweighs the increased risk of myopathy and rhabdomyolysis.
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Niacin Also Interacts With
- Atorvastatin moderate
- Ezetimibe moderate
- Ezetimibe/Simvastatin moderate
- Fluvastatin moderate
- Lovastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin + Niacin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's moderate band?
Rosuvastatin and Niacin tie at 21 labeled pairs each. moderate-band counts: Rosuvastatin 8 alongside Cyclosporine, Ledipasvir/Sofosbuvir, Colchicine, Gemfibrozil; Niacin 10 alongside Atorvastatin, Ezetimibe, Ezetimibe/Simvastatin, Fluvastatin.
What mechanism field is on file for Rosuvastatin and Niacin?
Using high doses of niacin with rosuvastatin can lead to serious muscle damage. Both drugs can affect your muscles, and the combination makes a toxic reaction more likely.
Rosuvastatin carries more major-labeled pairs than Niacin
SPL source-record counts only. This page's band is moderate · classes on file: Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)); Niacin (Vitamin B3 (Lipid-Modifying)).
Rosuvastatin has 3 major-labeled pairs vs Niacin's 0. This page itself is in the moderate band, not the major band.
3 major · 8 moderate · 10 minor · 21 total
- Other moderate peers for Rosuvastatin
- Cyclosporine
- Ledipasvir/Sofosbuvir
- Colchicine
- Gemfibrozil
0 major · 10 moderate · 11 minor · 21 total
- Other moderate peers for Niacin
- Atorvastatin
- Ezetimibe
- Ezetimibe/Simvastatin
- Fluvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.