Rosuvastatin and Gemfibrozil Interaction
Drug interaction information between Rosuvastatin and Gemfibrozil.
Rosuvastatin and Gemfibrozil have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rosuvastatin and Gemfibrozil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Gemfibrozil increases the amount of rosuvastatin in your body and can also cause muscle damage on its own. Taking them together significantly raises the chance of a dangerous muscle condition.
FDA Label Information
The risk of myopathy and rhabdomyolysis is increased with concomitant use of cyclosporine or gemfibrozil with rosuvastatin. Gemfibrozil Clinical Impact: Gemfibrozil significantly increased rosuvastatin exposure and gemfibrozil may cause myopathy when given alone. The risk of myopathy and rhabdomyolysis is increased with concomitant use of gemfibrozil with rosuvastatin.
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin + Gemfibrozil?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rosuvastatin has 21 labeled pairs on file vs Gemfibrozil's 20. In the moderate band specifically: Rosuvastatin has 8 (also Cyclosporine, Ledipasvir/Sofosbuvir, Colchicine, Niacin); Gemfibrozil has 8 (also Atorvastatin, Eluxadoline, Fluvastatin, Lovastatin).
What mechanism field is on file for Rosuvastatin and Gemfibrozil?
Gemfibrozil increases the amount of rosuvastatin in your body and can also cause muscle damage on its own. Taking them together significantly raises the chance of a dangerous muscle condition.
Gemfibrozil carries more major-labeled pairs than Rosuvastatin
SPL source-record counts only. This page's band is moderate · classes on file: Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)); Gemfibrozil (Fibrate).
Gemfibrozil has 4 major-labeled pairs vs Rosuvastatin's 3. This page itself is in the moderate band, not the major band.
3 major · 8 moderate · 10 minor · 21 total
- Other moderate peers for Rosuvastatin
- Cyclosporine
- Ledipasvir/Sofosbuvir
- Colchicine
- Niacin
4 major · 8 moderate · 8 minor · 20 total
- Other moderate peers for Gemfibrozil
- Atorvastatin
- Eluxadoline
- Fluvastatin
- Lovastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.