Diclofenac and Digoxin Interaction
Drug interaction information between Diclofenac and Digoxin.
Diclofenac and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diclofenac and Digoxin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Diclofenac may cause the amount of digoxin in your body to increase. It is not clear exactly how much the levels will change when these drugs are used together.
What To Do
Your doctor should measure your digoxin blood levels before you start taking diclofenac.
FDA Label Information
Conivaptan 33% 43% Diltiazem 20% NA Indomethacin 40% NA Mirabegron 29% 27% Nefazodone 27% 15% Nifedipine 45% NA Propantheline 24% 24% Quinine NA 33% Rabeprazole 29% 19% Saquinavir 27% 49% Spironolactone 25% NA Telmisartan 20 to 49% NA Tricagrelor 31% 28% Tolvaptan 30% 20% Trimethoprim 22 to 28% NA Digoxin concentrations increased, but magnitude is unclear Alprazolam, azithromycin, cyclosporine, diclofenac, diphenoxylate, epoprostenol, esomeprazole, ibuprofen, ketoconazole, lansoprazole, metformin, omeprazole Measure serum digoxin concentrations before initiating concomitant drugs.
Diclofenac Also Interacts With
- Misoprostol moderate
- Warfarin moderate
- Celecoxib minor
- Fluconazole minor
- Indomethacin minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
Can I take Diclofenac and Digoxin together?
This is a minor interaction. Your doctor should measure your digoxin blood levels before you start taking diclofenac.
How serious is the interaction between Diclofenac and Digoxin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Diclofenac and Digoxin interact?
Diclofenac may cause the amount of digoxin in your body to increase. It is not clear exactly how much the levels will change when these drugs are used together.
Understanding the Diclofenac and Digoxin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Diclofenac belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class and Digoxin belongs to the Cardiac Glycoside class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Diclofenac may cause the amount of digoxin in your body to increase. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Diclofenac has 11 total documented interactions on file in this dataset, and Digoxin has 120. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should measure your digoxin blood levels before you start taking diclofenac. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Diclofenac or Digoxin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.