Diclofenac and Digoxin Interaction
Drug interaction information between Diclofenac and Digoxin.
Diclofenac and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diclofenac and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diclofenac may cause the amount of digoxin in your body to increase. It is not clear exactly how much the levels will change when these drugs are used together.
FDA Label Information
Conivaptan 33% 43% Diltiazem 20% NA Indomethacin 40% NA Mirabegron 29% 27% Nefazodone 27% 15% Nifedipine 45% NA Propantheline 24% 24% Quinine NA 33% Rabeprazole 29% 19% Saquinavir 27% 49% Spironolactone 25% NA Telmisartan 20 to 49% NA Tricagrelor 31% 28% Tolvaptan 30% 20% Trimethoprim 22 to 28% NA Digoxin concentrations increased, but magnitude is unclear Alprazolam, azithromycin, cyclosporine, diclofenac, diphenoxylate, epoprostenol, esomeprazole, ibuprofen, ketoconazole, lansoprazole, metformin, omeprazole Measure serum digoxin concentrations before initiating concomitant drugs.
Diclofenac Also Interacts With
- Misoprostol moderate
- Warfarin moderate
- Celecoxib minor
- Fluconazole minor
- Indomethacin minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Diclofenac + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Diclofenac's 11. In the minor band specifically: Diclofenac has 9 (also Celecoxib, Fluconazole, Indomethacin, Mefenamic Acid); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Ketoconazole).
What mechanism field is on file for Diclofenac and Digoxin?
Diclofenac may cause the amount of digoxin in your body to increase. It is not clear exactly how much the levels will change when these drugs are used together.
Digoxin carries more major-labeled pairs than Diclofenac
SPL source-record counts only. This page's band is minor · classes on file: Diclofenac (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Diclofenac's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 9 minor · 11 total
- Other minor peers for Diclofenac
- Celecoxib
- Fluconazole
- Indomethacin
- Mefenamic Acid
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.