Diclofenac and Celecoxib Interaction
Drug interaction information between Diclofenac and Celecoxib.
Diclofenac and Celecoxib have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diclofenac and Celecoxib. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking two different NSAID pain relievers at the same time increases the chance of serious side effects like stomach ulcers or kidney issues.
FDA Label Information
NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.
Diclofenac Also Interacts With
- Misoprostol moderate
- Warfarin moderate
- Digoxin minor
- Fluconazole minor
- Indomethacin minor
Celecoxib Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Meloxicam minor
- Furosemide minor
Frequently Asked Questions
What SPL severity band is on file for Diclofenac + Celecoxib?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Celecoxib has 19 labeled pairs on file vs Diclofenac's 11. In the minor band specifically: Diclofenac has 9 (also Digoxin, Fluconazole, Indomethacin, Mefenamic Acid); Celecoxib has 16 (also Meloxicam, Furosemide, Aspirin, Propranolol).
What mechanism field is on file for Diclofenac and Celecoxib?
Taking two different NSAID pain relievers at the same time increases the chance of serious side effects like stomach ulcers or kidney issues.
Celecoxib's labeled portfolio outnumbers Diclofenac
SPL source-record counts only. This page's band is minor · classes on file: Diclofenac (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Celecoxib (COX-2 Selective NSAID).
0 major · 2 moderate · 9 minor · 11 total
- Other minor peers for Diclofenac
- Digoxin
- Fluconazole
- Indomethacin
- Mefenamic Acid
0 major · 3 moderate · 16 minor · 19 total
- Other minor peers for Celecoxib
- Meloxicam
- Furosemide
- Aspirin
- Propranolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.