Diclofenac and Misoprostol Interaction
Drug interaction information between Diclofenac and Misoprostol.
Diclofenac and Misoprostol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Diclofenac and Misoprostol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diclofenac can increase the risk of serious bleeding in the stomach. Misoprostol is used with it to help protect the lining of the stomach and reduce this risk.
FDA Label Information
7 DRUG INTERACTIONS See Table 1 for clinically significant drug interactions with diclofenac and misoprostol. Table 1: Clinically Significant Drug Interactions with Diclofenac and Misoprostol Drugs That Interfere with Hemostasis Clinical Impact: Diclofenac and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of diclofenac and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone.
Diclofenac Also Interacts With
- Warfarin moderate
- Celecoxib minor
- Digoxin minor
- Fluconazole minor
- Indomethacin minor
Misoprostol Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
Frequently Asked Questions
What SPL severity band is on file for Diclofenac + Misoprostol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Misoprostol has 12 labeled pairs on file vs Diclofenac's 11. In the moderate band specifically: Diclofenac has 2 (also Warfarin); Misoprostol has 3 (also Methotrexate, Diflunisal).
What mechanism field is on file for Diclofenac and Misoprostol?
Diclofenac can increase the risk of serious bleeding in the stomach. Misoprostol is used with it to help protect the lining of the stomach and reduce this risk.
Misoprostol's labeled portfolio outnumbers Diclofenac
SPL source-record counts only. This page's band is moderate · classes on file: Diclofenac (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Misoprostol (Prostaglandin E1 Analog).
0 major · 3 moderate · 9 minor · 12 total
- Other moderate peers for Misoprostol
- Methotrexate
- Diflunisal
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.