Indomethacin and Lithium Interaction
Drug interaction information between Indomethacin and Lithium.
Indomethacin and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Indomethacin and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Indomethacin slows down how fast your kidneys remove lithium from your body, which can cause lithium to build up to unsafe levels.
FDA Label Information
Lithium Clinical Impact: NSAIDs have produced elevations in plasma lithium levels and reductions in renal lithium clearance . The mean minimum lithium concentration increased 15%, and the renal clearance decreased by approximately 20%. Intervention: During concomitant use of indomethacin capsules and lithium, monitor patients for signs of lithium toxicity.
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Perindopril moderate
- Warfarin moderate
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Indomethacin + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Indomethacin's 35. In the minor band specifically: Indomethacin has 30 (also Meloxicam, Aspirin, Diclofenac, Cyclosporine); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Indomethacin and Lithium?
Indomethacin slows down how fast your kidneys remove lithium from your body, which can cause lithium to build up to unsafe levels.
Lithium carries more major-labeled pairs than Indomethacin
SPL source-record counts only. This page's band is minor · classes on file: Indomethacin (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Indomethacin's 0. This page itself is in the minor band, not the major band.
0 major · 5 moderate · 30 minor · 35 total
- Other minor peers for Indomethacin
- Meloxicam
- Aspirin
- Diclofenac
- Cyclosporine
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.