Diclofenac and Fluconazole Interaction
Drug interaction information between Diclofenac and Fluconazole.
Diclofenac and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diclofenac and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole blocks the liver protein that normally clears diclofenac, causing the pain medicine to build up in your system.
FDA Label Information
Although not specifically studied, fluconazole has the potential to increase the systemic exposure of other non-steroidal anti-inflammatory drugs (NSAIDs) that are metabolized by CYP2C9 (e.g., naproxen, lornoxicam, meloxicam, diclofenac).
Diclofenac Also Interacts With
- Misoprostol moderate
- Warfarin moderate
- Celecoxib minor
- Digoxin minor
- Indomethacin minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Diclofenac + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Diclofenac's 11. In the minor band specifically: Diclofenac has 9 (also Celecoxib, Digoxin, Indomethacin, Mefenamic Acid); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Diclofenac and Fluconazole?
Fluconazole blocks the liver protein that normally clears diclofenac, causing the pain medicine to build up in your system.
Fluconazole carries more major-labeled pairs than Diclofenac
SPL source-record counts only. This page's band is minor · classes on file: Diclofenac (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Diclofenac's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 9 minor · 11 total
- Other minor peers for Diclofenac
- Celecoxib
- Digoxin
- Indomethacin
- Mefenamic Acid
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.