Diclofenac and Mefenamic Acid Interaction
Drug interaction information between Diclofenac and Mefenamic Acid.
Diclofenac and Mefenamic Acid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diclofenac and Mefenamic Acid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking two different NSAID pain relievers together increases the risk of serious side effects like stomach bleeding and kidney problems.
FDA Label Information
NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.
Diclofenac Also Interacts With
- Misoprostol moderate
- Warfarin moderate
- Celecoxib minor
- Digoxin minor
- Fluconazole minor
Mefenamic Acid Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Warfarin moderate
- Meloxicam minor
- Furosemide minor
Frequently Asked Questions
What SPL severity band is on file for Diclofenac + Mefenamic Acid?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Mefenamic Acid has 15 labeled pairs on file vs Diclofenac's 11. In the minor band specifically: Diclofenac has 9 (also Celecoxib, Digoxin, Fluconazole, Indomethacin); Mefenamic Acid has 12 (also Meloxicam, Furosemide, Aspirin, Propranolol).
What mechanism field is on file for Diclofenac and Mefenamic Acid?
Taking two different NSAID pain relievers together increases the risk of serious side effects like stomach bleeding and kidney problems.
Mefenamic Acid's labeled portfolio outnumbers Diclofenac
SPL source-record counts only. This page's band is minor · classes on file: Diclofenac (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Mefenamic Acid (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 2 moderate · 9 minor · 11 total
- Other minor peers for Diclofenac
- Celecoxib
- Digoxin
- Fluconazole
- Indomethacin
0 major · 3 moderate · 12 minor · 15 total
- Other minor peers for Mefenamic Acid
- Meloxicam
- Furosemide
- Aspirin
- Propranolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.