Hydroxychloroquine and Cyclosporine Interaction
Drug interaction information between Hydroxychloroquine and Cyclosporine.
Hydroxychloroquine and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydroxychloroquine and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Hydroxychloroquine can cause the amount of cyclosporine in your blood to rise to higher levels.
FDA Label Information
7.6 Cyclosporine An increased plasma cyclosporine level was reported when cyclosporine and hydroxychloroquine sulfate tablets were co-administered. Monitor serum cyclosporine levels closely in patients receiving combined therapy.
Hydroxychloroquine Also Interacts With
- Chloroquine moderate
- Cimetidine moderate
- Heparin moderate
- Remdesivir moderate
- Methotrexate minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Hydroxychloroquine + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Hydroxychloroquine's 7. In the minor band specifically: Hydroxychloroquine has 3 (also Methotrexate, Digoxin); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Hydroxychloroquine and Cyclosporine?
Hydroxychloroquine can cause the amount of cyclosporine in your blood to rise to higher levels.
Cyclosporine carries more major-labeled pairs than Hydroxychloroquine
SPL source-record counts only. This page's band is minor · classes on file: Hydroxychloroquine (Disease-Modifying Antirheumatic Drug (DMARD)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Hydroxychloroquine's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 3 minor · 7 total
- Other minor peers for Hydroxychloroquine
- Methotrexate
- Digoxin
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.