Hydroxychloroquine and Heparin Interaction
Drug interaction information between Hydroxychloroquine and Heparin.
Hydroxychloroquine and Heparin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Hydroxychloroquine and Heparin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Hydroxychloroquine can interfere with how blood cells stick together to stop bleeding. When taken with a blood thinner like heparin, it increases the chance of serious bleeding.
FDA Label Information
7.2 Platelet Inhibitors Drugs such as NSAIDS (including salicylic acid, ibuprofen, indomethacin, and celecoxib), dextran, phenylbutazone, thienopyridines, dipyridamole, hydroxychloroquine, glycoprotein IIb/IIIa antagonists (including abciximab, eptifibatide, and tirofiban), and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium.
Hydroxychloroquine Also Interacts With
- Chloroquine moderate
- Cimetidine moderate
- Remdesivir moderate
- Methotrexate minor
- Cyclosporine minor
Heparin Also Interacts With
- Ibuprofen moderate
- Celecoxib moderate
- Indomethacin moderate
- Dipyridamole moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Hydroxychloroquine + Heparin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Heparin has 20 labeled pairs on file vs Hydroxychloroquine's 7. In the moderate band specifically: Hydroxychloroquine has 4 (also Chloroquine, Cimetidine, Remdesivir); Heparin has 10 (also Ibuprofen, Celecoxib, Indomethacin, Dipyridamole).
What mechanism field is on file for Hydroxychloroquine and Heparin?
Hydroxychloroquine can interfere with how blood cells stick together to stop bleeding. When taken with a blood thinner like heparin, it increases the chance of serious bleeding.
Heparin's labeled portfolio outnumbers Hydroxychloroquine
SPL source-record counts only. This page's band is moderate · classes on file: Hydroxychloroquine (Disease-Modifying Antirheumatic Drug (DMARD)); Heparin (Unfractionated Heparin).
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Hydroxychloroquine
- Chloroquine
- Cimetidine
- Remdesivir
0 major · 10 moderate · 10 minor · 20 total
- Other moderate peers for Heparin
- Ibuprofen
- Celecoxib
- Indomethacin
- Dipyridamole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.