Hydroxychloroquine and Digoxin Interaction
Drug interaction information between Hydroxychloroquine and Digoxin.
Hydroxychloroquine and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydroxychloroquine and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking hydroxychloroquine can lead to higher levels of digoxin in your bloodstream.
FDA Label Information
7.7 Digoxin Concomitant hydroxychloroquine sulfate tablets and digoxin therapy may result in increased serum digoxin levels. Monitor serum digoxin levels closely in patients receiving combined therapy.
Hydroxychloroquine Also Interacts With
- Chloroquine moderate
- Cimetidine moderate
- Heparin moderate
- Remdesivir moderate
- Methotrexate minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Hydroxychloroquine + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Hydroxychloroquine's 7. In the minor band specifically: Hydroxychloroquine has 3 (also Methotrexate, Cyclosporine); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Hydroxychloroquine and Digoxin?
Taking hydroxychloroquine can lead to higher levels of digoxin in your bloodstream.
Digoxin carries more major-labeled pairs than Hydroxychloroquine
SPL source-record counts only. This page's band is minor · classes on file: Hydroxychloroquine (Disease-Modifying Antirheumatic Drug (DMARD)); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Hydroxychloroquine's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 3 minor · 7 total
- Other minor peers for Hydroxychloroquine
- Methotrexate
- Cyclosporine
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.