What the FDA labels say about taking them together
Digoxin and hydroxychloroquine
Hydroxychloroquine's FDA label of October 8, 2024 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name hydroxychloroquine. The hydroxychloroquine label: “Digoxin Concomitant SOVUNA and digoxin therapy may result in increased serum digoxin levels.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the hydroxychloroquine FDA label on DailyMed (effective October 8, 2024, ANI Pharmaceuticals, Inc.).
What does the digoxin label say about hydroxychloroquine?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name hydroxychloroquine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the hydroxychloroquine label say about digoxin?
Hydroxychloroquine label, drug interactionsDigoxin Concomitant SOVUNA and digoxin therapy may result in increased serum digoxin levels.
Source: FDA drug label (Plaquenil, NDA009768), Advanz Pharma (US) Corp., effective April 9, 2026 (SPL set 34496b43-05a2-45fb-a769-52b12e099341), via openFDA
Source: FDA drug label (SOVUNA), ANI Pharmaceuticals, Inc., effective October 8, 2024 (SPL set dd441154-b196-4d4c-bc56-2e37f345ef8d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Hydroxychloroquine | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Rheumatoid arthritis |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $0.149 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once