Hydroxychloroquine and Methotrexate Interaction
Drug interaction information between Hydroxychloroquine and Methotrexate.
Hydroxychloroquine and Methotrexate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydroxychloroquine and Methotrexate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two medications at the same time can make it more likely that you will experience side effects.
FDA Label Information
7.5 Methotrexate Concomitant use of hydroxychloroquine sulfate tablets and methotrexate may increase the incidence of adverse reactions.
Hydroxychloroquine Also Interacts With
- Chloroquine moderate
- Cimetidine moderate
- Heparin moderate
- Remdesivir moderate
- Cyclosporine minor
Methotrexate Also Interacts With
- Celecoxib moderate
- Diflunisal moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
Frequently Asked Questions
What SPL severity band is on file for Hydroxychloroquine + Methotrexate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methotrexate has 38 labeled pairs on file vs Hydroxychloroquine's 7. In the minor band specifically: Hydroxychloroquine has 3 (also Cyclosporine, Digoxin); Methotrexate has 26 (also Aspirin, Folic Acid, Probenecid, Phenytoin).
What mechanism field is on file for Hydroxychloroquine and Methotrexate?
Using these two medications at the same time can make it more likely that you will experience side effects.
Methotrexate's labeled portfolio outnumbers Hydroxychloroquine
SPL source-record counts only. This page's band is minor · classes on file: Hydroxychloroquine (Disease-Modifying Antirheumatic Drug (DMARD)); Methotrexate (Disease-Modifying Antirheumatic Drug (DMARD)).
0 major · 4 moderate · 3 minor · 7 total
- Other minor peers for Hydroxychloroquine
- Cyclosporine
- Digoxin
0 major · 12 moderate · 26 minor · 38 total
- Other minor peers for Methotrexate
- Aspirin
- Folic Acid
- Probenecid
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.