What the FDA labels say about taking them together
Chloroquine and hydroxychloroquine
Hydroxychloroquine's FDA label of October 8, 2024 names chloroquine in its drug interactions section; the chloroquine label PlainMeds reads does not name hydroxychloroquine. The hydroxychloroquine label: “Concomitant use of cimetidine resulted in a 2-fold increase of exposure of chloroquine, which is structurally related to hydroxychloroquine.”
Check it at the source: the chloroquine FDA label on DailyMed (effective July 2, 2026, Rising Pharma Holdings, Inc.); the hydroxychloroquine FDA label on DailyMed (effective October 8, 2024, ANI Pharmaceuticals, Inc.).
What does the chloroquine label say about hydroxychloroquine?
Chloroquine's label (effective July 2, 2026) does not name hydroxychloroquine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Chloroquine Phosphate), Rising Pharma Holdings, Inc., effective July 2, 2026 (SPL set 06c69e2b-211b-4746-9f3a-f86d36520570), via openFDA; the full label on DailyMed
What does the hydroxychloroquine label say about chloroquine?
Hydroxychloroquine label, drug interactionsConcomitant use of cimetidine resulted in a 2-fold increase of exposure of chloroquine, which is structurally related to hydroxychloroquine.
Source: FDA drug label (SOVUNA), ANI Pharmaceuticals, Inc., effective October 8, 2024 (SPL set dd441154-b196-4d4c-bc56-2e37f345ef8d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Chloroquine | Hydroxychloroquine | |
|---|---|---|
| Labeled for | n/a | Rheumatoid arthritis |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $6.65 per tablet 500 mg tablet | $0.149 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once