Heparin and Amlodipine/Valsartan Interaction
Drug interaction information between Heparin and Amlodipine/Valsartan.
Heparin and Amlodipine/Valsartan have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Heparin and Amlodipine/Valsartan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both medications can cause potassium levels in your blood to rise, which can affect your heart and kidneys.
FDA Label Information
Valsartan Agents Increasing Serum Potassium: Concomitant use of valsartan with other agents that block the renin-angiotensin system, potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium or other drugs that may increase potassium levels (e.g., heparin) may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine.
Heparin Also Interacts With
- Ibuprofen moderate
- Celecoxib moderate
- Hydroxychloroquine moderate
- Indomethacin moderate
- Dipyridamole moderate
Amlodipine/Valsartan Also Interacts With
- Simvastatin major
- Aliskiren major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine minor
Frequently Asked Questions
What SPL severity band is on file for Heparin + Amlodipine/Valsartan?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Heparin has 20 labeled pairs on file vs Amlodipine/Valsartan's 14. In the minor band specifically: Heparin has 10 (also Nitroglycerin, Levothyroxine, Liothyronine, Oritavancin); Amlodipine/Valsartan has 10 (also Amlodipine, Hydrochlorothiazide, Spironolactone, Valsartan).
What mechanism field is on file for Heparin and Amlodipine/Valsartan?
Both medications can cause potassium levels in your blood to rise, which can affect your heart and kidneys.
Amlodipine/Valsartan carries more major-labeled pairs than Heparin
SPL source-record counts only. This page's band is minor · classes on file: Heparin (Unfractionated Heparin); Amlodipine/Valsartan (CCB / ARB Combination).
Amlodipine/Valsartan has 2 major-labeled pairs vs Heparin's 0. This page itself is in the minor band, not the major band.
0 major · 10 moderate · 10 minor · 20 total
- Other minor peers for Heparin
- Nitroglycerin
- Levothyroxine
- Liothyronine
- Oritavancin
2 major · 2 moderate · 10 minor · 14 total
- Other minor peers for Amlodipine/Valsartan
- Amlodipine
- Hydrochlorothiazide
- Spironolactone
- Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.