Amlodipine/Valsartan and Hydrochlorothiazide Interaction
Drug interaction information between Amlodipine/Valsartan and Hydrochlorothiazide.
Amlodipine/Valsartan and Hydrochlorothiazide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amlodipine/Valsartan and Hydrochlorothiazide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these together can change how your body handles fluids and salts. It may also change how well your diabetes medications or other drugs like lithium work.
FDA Label Information
Valsartan – Hydrochlorothiazide Lithium: Increases in serum lithium concentrations and lithium toxicity have been reported during concomitant administration of lithium with angiotensin II receptor antagonists or thiazides. Hydrochlorothiazide When administered concurrently, the following drugs may interact with thiazide diuretics: Antidiabetic Drugs (oral agents and insulin): Dosage adjustment of the antidiabetic drug may be required. Ion Exchange Resins: Staggering the dosage of hydrochlorothiazide and ion exchange resins (e.g., cholestyramine, colestipol) such that hydrochlorothiazide is...
Amlodipine/Valsartan Also Interacts With
- Simvastatin major
- Aliskiren major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine minor
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Lisinopril major
- Olmesartan moderate
- Losartan minor
Frequently Asked Questions
What SPL severity band is on file for Amlodipine/Valsartan + Hydrochlorothiazide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydrochlorothiazide has 31 labeled pairs on file vs Amlodipine/Valsartan's 14. In the minor band specifically: Amlodipine/Valsartan has 10 (also Amlodipine, Spironolactone, Valsartan, Sildenafil); Hydrochlorothiazide has 27 (also Losartan, Spironolactone, Propranolol, Lithium).
What mechanism field is on file for Amlodipine/Valsartan and Hydrochlorothiazide?
Using these together can change how your body handles fluids and salts. It may also change how well your diabetes medications or other drugs like lithium work.
Hydrochlorothiazide carries more major-labeled pairs than Amlodipine/Valsartan
SPL source-record counts only. This page's band is minor · classes on file: Amlodipine/Valsartan (CCB / ARB Combination); Hydrochlorothiazide (Thiazide Diuretic).
Hydrochlorothiazide has 3 major-labeled pairs vs Amlodipine/Valsartan's 2. This page itself is in the minor band, not the major band.
2 major · 2 moderate · 10 minor · 14 total
- Other minor peers for Amlodipine/Valsartan
- Amlodipine
- Spironolactone
- Valsartan
- Sildenafil
3 major · 1 moderate · 27 minor · 31 total
- Other minor peers for Hydrochlorothiazide
- Losartan
- Spironolactone
- Propranolol
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.