Amlodipine/Valsartan and Valsartan Interaction
Drug interaction information between Amlodipine/Valsartan and Valsartan.
Amlodipine/Valsartan and Valsartan have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amlodipine/Valsartan and Valsartan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking both of these medications results in a double dose of valsartan. This increases your risk for high potassium levels, kidney damage, and very low blood pressure.
FDA Label Information
Valsartan Agents Increasing Serum Potassium: Concomitant use of valsartan with other agents that block the renin-angiotensin system, potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium or other drugs that may increase potassium levels (e.g., heparin) may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine. Non-Steroidal Anti-Inflammatory (NSAID) Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors): In patients who are elderly,...
Amlodipine/Valsartan Also Interacts With
- Simvastatin major
- Aliskiren major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine minor
Valsartan Also Interacts With
- Sacubitril/Valsartan major
- Aliskiren major
- Lithium moderate
- Spironolactone minor
- Amiloride minor
Frequently Asked Questions
What SPL severity band is on file for Amlodipine/Valsartan + Valsartan?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amlodipine/Valsartan has 14 labeled pairs on file vs Valsartan's 8. In the minor band specifically: Amlodipine/Valsartan has 10 (also Amlodipine, Hydrochlorothiazide, Spironolactone, Sildenafil); Valsartan has 5 (also Spironolactone, Amiloride, Dapagliflozin, Glecaprevir/Pibrentasvir).
What mechanism field is on file for Amlodipine/Valsartan and Valsartan?
Taking both of these medications results in a double dose of valsartan. This increases your risk for high potassium levels, kidney damage, and very low blood pressure.
Amlodipine/Valsartan's labeled portfolio outnumbers Valsartan
SPL source-record counts only. This page's band is minor · classes on file: Amlodipine/Valsartan (CCB / ARB Combination); Valsartan (Angiotensin II Receptor Blocker (ARB)).
2 major · 2 moderate · 10 minor · 14 total
- Other minor peers for Amlodipine/Valsartan
- Amlodipine
- Hydrochlorothiazide
- Spironolactone
- Sildenafil
2 major · 1 moderate · 5 minor · 8 total
- Other minor peers for Valsartan
- Spironolactone
- Amiloride
- Dapagliflozin
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.