Amlodipine/Valsartan and Simvastatin Interaction
Drug interaction information between Amlodipine/Valsartan and Simvastatin.
Amlodipine/Valsartan and Simvastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Amlodipine/Valsartan and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amlodipine interferes with how the body processes simvastatin, leading to higher amounts of the cholesterol drug in your blood. This can increase your risk of experiencing muscle pain or damage.
FDA Label Information
Impact of Amlodipine on Other Drugs Simvastatin Coadministration of simvastatin with amlodipine increases the systemic exposure of simvastatin. Limit the dose of simvastatin in patients on amlodipine to 20 mg daily [see Clinical Pharmacology (12.3)] . If simvastatin is coadministered with amlodipine, do not exceed doses greater than 20 mg daily of simvastatin.
Amlodipine/Valsartan Also Interacts With
- Aliskiren major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine minor
- Hydrochlorothiazide minor
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Amlodipine/Valsartan + Simvastatin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Amlodipine/Valsartan's 14. In the major band specifically: Amlodipine/Valsartan has 2 (also Aliskiren); Simvastatin has 11 (also Diltiazem, Verapamil, Cyclosporine, Amiodarone).
What mechanism field is on file for Amlodipine/Valsartan and Simvastatin?
Amlodipine interferes with how the body processes simvastatin, leading to higher amounts of the cholesterol drug in your blood. This can increase your risk of experiencing muscle pain or damage.
Simvastatin carries more major-labeled pairs than Amlodipine/Valsartan
SPL source-record counts only. This page's band is major · classes on file: Amlodipine/Valsartan (CCB / ARB Combination); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Amlodipine/Valsartan's 2.
2 major · 2 moderate · 10 minor · 14 total
- Other major peers for Amlodipine/Valsartan
- Aliskiren
11 major · 9 moderate · 21 minor · 41 total
- Other major peers for Simvastatin
- Diltiazem
- Verapamil
- Cyclosporine
- Amiodarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.