Heparin and Indomethacin Interaction
Drug interaction information between Heparin and Indomethacin.
Heparin and Indomethacin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Heparin and Indomethacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs make it harder for your blood to clot, which increases the risk of bleeding. Indomethacin stops platelets from sticking together, while heparin thins the blood.
FDA Label Information
7.2 Platelet Inhibitors Drugs such as NSAIDS (including salicylic acid, ibuprofen, indomethacin, and celecoxib), dextran, phenylbutazone, thienopyridines, dipyridamole, hydroxychloroquine, glycoprotein IIb/IIIa antagonists (including abciximab, eptifibatide, and tirofiban), and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium.
Heparin Also Interacts With
- Ibuprofen moderate
- Celecoxib moderate
- Hydroxychloroquine moderate
- Dipyridamole moderate
- Apixaban moderate
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Perindopril moderate
- Warfarin moderate
- Meloxicam minor
Frequently Asked Questions
What SPL severity band is on file for Heparin + Indomethacin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Indomethacin has 35 labeled pairs on file vs Heparin's 20. In the moderate band specifically: Heparin has 10 (also Ibuprofen, Celecoxib, Hydroxychloroquine, Dipyridamole); Indomethacin has 5 (also Methotrexate, Diflunisal, Perindopril, Warfarin).
What mechanism field is on file for Heparin and Indomethacin?
Both drugs make it harder for your blood to clot, which increases the risk of bleeding. Indomethacin stops platelets from sticking together, while heparin thins the blood.
Indomethacin's labeled portfolio outnumbers Heparin
SPL source-record counts only. This page's band is moderate · classes on file: Heparin (Unfractionated Heparin); Indomethacin (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 10 moderate · 10 minor · 20 total
- Other moderate peers for Heparin
- Ibuprofen
- Celecoxib
- Hydroxychloroquine
- Dipyridamole
0 major · 5 moderate · 30 minor · 35 total
- Other moderate peers for Indomethacin
- Methotrexate
- Diflunisal
- Perindopril
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.