Heparin and Dipyridamole Interaction
Drug interaction information between Heparin and Dipyridamole.
Heparin and Dipyridamole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Heparin and Dipyridamole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both interfere with how your blood clots, making it more likely that you will bleed. Dipyridamole stops blood cells from clumping together while heparin works as a blood thinner.
FDA Label Information
7.2 Platelet Inhibitors Drugs such as NSAIDS (including salicylic acid, ibuprofen, indomethacin, and celecoxib), dextran, phenylbutazone, thienopyridines, dipyridamole, hydroxychloroquine, glycoprotein IIb/IIIa antagonists (including abciximab, eptifibatide, and tirofiban), and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium.
Heparin Also Interacts With
- Ibuprofen moderate
- Celecoxib moderate
- Hydroxychloroquine moderate
- Indomethacin moderate
- Apixaban moderate
Dipyridamole Also Interacts With
- Warfarin moderate
- Adenosine minor
- Enoxaparin minor
- Nicardipine minor
Frequently Asked Questions
What SPL severity band is on file for Heparin + Dipyridamole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Heparin has 20 labeled pairs on file vs Dipyridamole's 5. In the moderate band specifically: Heparin has 10 (also Ibuprofen, Celecoxib, Hydroxychloroquine, Indomethacin); Dipyridamole has 2 (also Warfarin).
What mechanism field is on file for Heparin and Dipyridamole?
These drugs both interfere with how your blood clots, making it more likely that you will bleed. Dipyridamole stops blood cells from clumping together while heparin works as a blood thinner.
Heparin's labeled portfolio outnumbers Dipyridamole
SPL source-record counts only. This page's band is moderate · classes on file: Heparin (Unfractionated Heparin); Dipyridamole (Antiplatelet / Vasodilator).
0 major · 10 moderate · 10 minor · 20 total
- Other moderate peers for Heparin
- Ibuprofen
- Celecoxib
- Hydroxychloroquine
- Indomethacin
0 major · 2 moderate · 3 minor · 5 total
- Other moderate peers for Dipyridamole
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.