Heparin and Hydroxychloroquine Interaction
Drug interaction information between Heparin and Hydroxychloroquine.
Heparin and Hydroxychloroquine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Heparin and Hydroxychloroquine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Hydroxychloroquine can interfere with how blood cells stick together to stop bleeding. When taken with a blood thinner like heparin, it increases the chance of serious bleeding.
FDA Label Information
7.2 Platelet Inhibitors Drugs such as NSAIDS (including salicylic acid, ibuprofen, indomethacin, and celecoxib), dextran, phenylbutazone, thienopyridines, dipyridamole, hydroxychloroquine, glycoprotein IIb/IIIa antagonists (including abciximab, eptifibatide, and tirofiban), and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium.
Heparin Also Interacts With
- Ibuprofen moderate
- Celecoxib moderate
- Indomethacin moderate
- Dipyridamole moderate
- Apixaban moderate
Hydroxychloroquine Also Interacts With
- Chloroquine moderate
- Cimetidine moderate
- Remdesivir moderate
- Methotrexate minor
- Cyclosporine minor
Frequently Asked Questions
What SPL severity band is on file for Heparin + Hydroxychloroquine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Heparin has 20 labeled pairs on file vs Hydroxychloroquine's 7. In the moderate band specifically: Heparin has 10 (also Ibuprofen, Celecoxib, Indomethacin, Dipyridamole); Hydroxychloroquine has 4 (also Chloroquine, Cimetidine, Remdesivir).
What mechanism field is on file for Heparin and Hydroxychloroquine?
Hydroxychloroquine can interfere with how blood cells stick together to stop bleeding. When taken with a blood thinner like heparin, it increases the chance of serious bleeding.
Heparin's labeled portfolio outnumbers Hydroxychloroquine
SPL source-record counts only. This page's band is moderate · classes on file: Heparin (Unfractionated Heparin); Hydroxychloroquine (Disease-Modifying Antirheumatic Drug (DMARD)).
0 major · 10 moderate · 10 minor · 20 total
- Other moderate peers for Heparin
- Ibuprofen
- Celecoxib
- Indomethacin
- Dipyridamole
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Hydroxychloroquine
- Chloroquine
- Cimetidine
- Remdesivir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.