Heparin and Celecoxib Interaction
Drug interaction information between Heparin and Celecoxib.
Heparin and Celecoxib have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Heparin and Celecoxib. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs affect how your blood clots, with one thinning the blood and the other stopping platelets from clumping. This combination makes it much easier for you to bleed or bruise.
FDA Label Information
7.2 Platelet Inhibitors Drugs such as NSAIDS (including salicylic acid, ibuprofen, indomethacin, and celecoxib), dextran, phenylbutazone, thienopyridines, dipyridamole, hydroxychloroquine, glycoprotein IIb/IIIa antagonists (including abciximab, eptifibatide, and tirofiban), and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium.
Heparin Also Interacts With
- Ibuprofen moderate
- Hydroxychloroquine moderate
- Indomethacin moderate
- Dipyridamole moderate
- Apixaban moderate
Celecoxib Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Meloxicam minor
- Furosemide minor
- Aspirin minor
Frequently Asked Questions
What SPL severity band is on file for Heparin + Celecoxib?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Heparin has 20 labeled pairs on file vs Celecoxib's 19. In the moderate band specifically: Heparin has 10 (also Ibuprofen, Hydroxychloroquine, Indomethacin, Dipyridamole); Celecoxib has 3 (also Methotrexate, Diflunisal).
What mechanism field is on file for Heparin and Celecoxib?
Both drugs affect how your blood clots, with one thinning the blood and the other stopping platelets from clumping. This combination makes it much easier for you to bleed or bruise.
Heparin's labeled portfolio outnumbers Celecoxib
SPL source-record counts only. This page's band is moderate · classes on file: Heparin (Unfractionated Heparin); Celecoxib (COX-2 Selective NSAID).
0 major · 10 moderate · 10 minor · 20 total
- Other moderate peers for Heparin
- Ibuprofen
- Hydroxychloroquine
- Indomethacin
- Dipyridamole
0 major · 3 moderate · 16 minor · 19 total
- Other moderate peers for Celecoxib
- Methotrexate
- Diflunisal
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.