Amlodipine/Valsartan and Amlodipine Interaction
Drug interaction information between Amlodipine/Valsartan and Amlodipine.
Amlodipine/Valsartan and Amlodipine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amlodipine/Valsartan and Amlodipine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these drugs contain amlodipine, so taking them together results in a double dose. This can cause your blood pressure to drop too low and may cause swelling in your ankles.
What To Do
Do not take these two medications together. Your doctor will need to choose one or adjust the dose to keep you safe.
FDA Label Information
Amlodipine Impact of Other Drugs on Amlodipine CYP3A Inhibitors Coadministration with CYP3A inhibitors (moderate and strong) results in increased systemic exposure to amlodipine and may require dose reduction. Monitor for symptoms of hypotension and edema when amlodipine is coadministered with CYP3A inhibitors to determine the need for dose adjustment [see Clinical Pharmacology (12.3)] . CYP3A Inducers No information is available on the quantitative effects of CYP3A inducers on amlodipine.
Amlodipine/Valsartan Also Interacts With
- Simvastatin major
- Aliskiren major
- Cyclosporine moderate
- Lithium moderate
- Hydrochlorothiazide minor
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
Frequently Asked Questions
Can I take Amlodipine/Valsartan and Amlodipine together?
This is a minor interaction. Do not take these two medications together. Your doctor will need to choose one or adjust the dose to keep you safe.
How serious is the interaction between Amlodipine/Valsartan and Amlodipine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Amlodipine/Valsartan and Amlodipine interact?
Both of these drugs contain amlodipine, so taking them together results in a double dose. This can cause your blood pressure to drop too low and may cause swelling in your ankles.
Understanding the Amlodipine/Valsartan and Amlodipine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Amlodipine/Valsartan belongs to the CCB / ARB Combination class and Amlodipine belongs to the Calcium Channel Blocker class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these drugs contain amlodipine, so taking them together results in a double dose. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Amlodipine/Valsartan has 14 total documented interactions on file in this dataset, and Amlodipine has 15. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Do not take these two medications together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Amlodipine/Valsartan or Amlodipine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.