Griseofulvin and Cyclosporine Interaction
Drug interaction information between Griseofulvin and Cyclosporine.
Griseofulvin and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Griseofulvin and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Griseofulvin lowers the amount of cyclosporine in your blood, which can make the medicine work less well.
FDA Label Information
Cyclosporine levels may be reduced when administered concomitantly with griseofulvin, resulting in a decrease in the pharmacologic effects of cyclosporine.
Griseofulvin Also Interacts With
- Warfarin minor
- Drospirenone/Ethinyl Estradiol minor
- Estradiol minor
- Ethinyl Estradiol/Etonogestrel minor
- Ethinyl Estradiol/Levonorgestrel minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Griseofulvin + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Griseofulvin's 12. In the minor band specifically: Griseofulvin has 12 (also Warfarin, Drospirenone, Estradiol, Ethinyl Estradiol); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Griseofulvin and Cyclosporine?
Griseofulvin lowers the amount of cyclosporine in your blood, which can make the medicine work less well.
Cyclosporine carries more major-labeled pairs than Griseofulvin
SPL source-record counts only. This page's band is minor · classes on file: Griseofulvin (Antifungal); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Griseofulvin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 12 minor · 12 total
- Other minor peers for Griseofulvin
- Warfarin
- Drospirenone
- Estradiol
- Ethinyl Estradiol
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.