Griseofulvin and Drospirenone Interaction
Drug interaction information between Griseofulvin and Drospirenone.
Griseofulvin and Drospirenone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Griseofulvin and Drospirenone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Griseofulvin causes your body to get rid of birth control hormones more quickly than it should. This can make your birth control fail to prevent pregnancy.
FDA Label Information
Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampin, topiramate and products containing St.
Griseofulvin Also Interacts With
- Warfarin minor
- Cyclosporine minor
- Estradiol minor
- Ethinyl Estradiol/Etonogestrel minor
- Ethinyl Estradiol/Levonorgestrel minor
Drospirenone Also Interacts With
- Estradiol major
- Atorvastatin minor
- Omeprazole minor
- Lamotrigine minor
- Topiramate minor
Frequently Asked Questions
What SPL severity band is on file for Griseofulvin + Drospirenone/Ethinyl Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Drospirenone has 30 labeled pairs on file vs Griseofulvin's 12. In the minor band specifically: Griseofulvin has 12 (also Warfarin, Cyclosporine, Estradiol, Ethinyl Estradiol); Drospirenone has 29 (also Atorvastatin, Omeprazole, Lamotrigine, Topiramate).
What mechanism field is on file for Griseofulvin and Drospirenone/Ethinyl Estradiol?
Griseofulvin causes your body to get rid of birth control hormones more quickly than it should. This can make your birth control fail to prevent pregnancy.
Drospirenone carries more major-labeled pairs than Griseofulvin
SPL source-record counts only. This page's band is minor · classes on file: Griseofulvin (Antifungal); Drospirenone (Combined Oral Contraceptive).
Drospirenone has 1 major-labeled pair vs Griseofulvin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 12 minor · 12 total
- Other minor peers for Griseofulvin
- Warfarin
- Cyclosporine
- Estradiol
- Ethinyl Estradiol
1 major · 0 moderate · 29 minor · 30 total
- Other minor peers for Drospirenone
- Atorvastatin
- Omeprazole
- Lamotrigine
- Topiramate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.