cyclosporine vs griseofulvin
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Side-by-side comparison of cyclosporine and griseofulvin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Cyclosporine levels may be reduced when administered concomitantly with griseofulvin, resulting in a decrease in the pharmacologic effects of cyclosporine.
Neoral, Sandimmune, Restasis
Grifulvin V
Vevye eye drops contain cyclosporine. They help treat the signs and symptoms of dry eye disease.
Griseofulvin is an antifungal medicine. It treats fungal infections of the skin, hair, and nails.
Vevye treats the signs and symptoms of dry eye disease. Dry eye can cause discomfort, stinging, and blurred vision. This medicine can help reduce these symptoms.
This medicine treats fungal infections called dermatophyte infections. These infections can affect your skin (tinea corporis, tinea cruris, tinea barbae), feet (tinea pedis), scalp (tinea capitis), or nails (tinea unguium). Make sure a lab test confirms you have a fungal infection before you start taking this medicine. This medicine will not work for bacterial or yeast infections.
Vevye contains cyclosporine, which is an immunosuppressant. It works by decreasing inflammation in the eyes. This helps your eyes make more tears.
Griseofulvin stops fungi from growing and multiplying. It binds to a protein in the fungi. This disrupts the fungi's cell structure and prevents it from spreading.
- • Irritation where the drops are applied (8%)
- • Headache
- • Nausea
- • Vomiting
- • Diarrhea
- • Fatigue
- Eye Irritation 7,786
- Pyrexia 4,064
- Eye Pain 3,808
- Nausea 3,623
- Diarrhoea 3,562
- Headache 15
- Pyrexia 11
- Rash 11
- Diarrhoea 10
- Drug Hypersensitivity 10
To avoid eye injury or contamination, do not touch the bottle tip to your eye or any other surface. Do not use Vevye while wearing contact lenses. If you wear contacts, remove them before using the drops. You can put them back in 15 minutes after using Vevye.
Griseofulvin can cause liver problems. If you have liver failure or a history of sensitivity to griseofulvin, you should not take this medicine. Do not take this medicine if you have porphyria. Griseofulvin can harm an unborn baby, so do not take it if you are pregnant or could become pregnant.
It is not known if Vevye will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Cyclosporine can pass into breast milk after being taken orally, but it is unknown if it passes into breast milk from eye drops. Talk to your doctor if you are breastfeeding.
Do not take this medicine if you are pregnant. It can cause harm to your unborn baby. Talk to your doctor about birth control options if you are a woman who could become pregnant.
How to Read This cyclosporine vs griseofulvin Comparison
cyclosporine is classified in the Calcineurin Inhibitor (Immunosuppressant) drug class, while griseofulvin sits within the Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cyclosporine has 22,843 submissions while griseofulvin has 57. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to griseofulvin lowers the amount of cyclosporine in your blood, which can make the medicine work less well.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for cyclosporine or griseofulvin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.