fluticasone/salmeterol vs salmeterol
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Side-by-side comparison of fluticasone/salmeterol and salmeterol. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
May potentiate effect of salmeterol on vascular system. ( 7.4 ) 7.1 Inhibitors of Cytochrome P450 3A4 Fluticasone propionate and salmeterol, the individual components of ADVAIR DISKUS, are substrates of CYP3A4. Salmeterol: In a drug interaction trial in 20 healthy subjects, coadministration of inhaled salmeterol (50 mcg twice daily) and oral ketoconazole (400 mg once daily) for 7 days resulted in greater systemic exposure to salmeterol (AUC increased 16-fold and C max increased 1.4-fold).
Advair
Serevent
Advair Diskus is a medicine that contains a steroid and a long-acting bronchodilator. It helps to control asthma and COPD by reducing inflammation and opening airways in the lungs.
No summary available.
Advair Diskus is used to treat asthma in people 4 years and older. It helps control asthma when other long-term medicines don't work well enough. It is also used to treat COPD, including chronic bronchitis and emphysema, helping to improve airflow and prevent flare-ups.
Information not available.
Advair Diskus contains two medicines. Fluticasone is a steroid that reduces swelling in your lungs. Salmeterol is a long-acting bronchodilator that relaxes the muscles around your airways, making it easier to breathe.
Information not available.
- • Upper respiratory infection
- • Sore throat
- • Hoarseness
- • Oral thrush (candidiasis)
- • Bronchitis
- • Nasopharyngitis (common cold)
- • Oral candidiasis (thrush)
- • Headache
- • Cough
- • Back pain
No adverse event reports.
No adverse event reports.
Long-acting beta-agonists (LABAs) like salmeterol can increase the risk of asthma-related death. Do not use Advair Diskus to treat sudden asthma symptoms. Do not use other medicines containing a LABA. Watch for signs of pneumonia if you have COPD.
No specific warnings noted.
It is not known if Advair Diskus will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if Advair Diskus passes into breast milk. Talk to your doctor about the risks and benefits of using Advair Diskus while breastfeeding.
No pregnancy information available.
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How to Read This fluticasone/salmeterol vs salmeterol Comparison
fluticasone/salmeterol is classified in the Corticosteroid / Long-Acting Beta-2 Agonist Combination drug class, while salmeterol sits within the Long-Acting Beta-2 Agonist (LABA) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluticasone/salmeterol has 0 submissions while salmeterol has 0. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these two products contain the same active ingredient. taking both at once can lead to an overdose, which may cause heart or blood pressure problems.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for fluticasone/salmeterol or salmeterol.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.