Darunavir and Quetiapine Interaction
Drug interaction information between Darunavir and Quetiapine.
Darunavir and Quetiapine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Darunavir and Quetiapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir slows down how fast your body processes quetiapine, which can lead to dangerously high levels of the drug in your system.
FDA Label Information
quetiapine ↑ quetiapine Initiation of darunavir with ritonavir in patients taking quetiapine: Consider alternative antiretroviral therapy to avoid increases in quetiapine exposures. If co-administration is necessary, reduce the quetiapine dose to 1/6 of the current dose and monitor for quetiapine-associated adverse reactions. Refer to the quetiapine prescribing information for recommendations on adverse reaction monitoring.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Quetiapine Also Interacts With
- Clarithromycin major
- Ketoconazole minor
- Carbamazepine minor
- Rifampin minor
- Itraconazole minor
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Quetiapine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Quetiapine's 9. In the moderate band specifically: Darunavir has 16 (also Omeprazole, Fluticasone, Apixaban, Clopidogrel); Quetiapine has 1.
What mechanism field is on file for Darunavir and Quetiapine?
Darunavir slows down how fast your body processes quetiapine, which can lead to dangerously high levels of the drug in your system.
Darunavir carries more major-labeled pairs than Quetiapine
SPL source-record counts only. This page's band is moderate · classes on file: Darunavir (HIV Protease Inhibitor); Quetiapine (Atypical Antipsychotic).
Darunavir has 15 major-labeled pairs vs Quetiapine's 1. This page itself is in the moderate band, not the major band.
15 major · 16 moderate · 70 minor · 101 total
- Other moderate peers for Darunavir
- Omeprazole
- Fluticasone
- Apixaban
- Clopidogrel
1 major · 1 moderate · 7 minor · 9 total
Quetiapine has no other moderate-band peer in this dataset besides Darunavir.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.