What the FDA labels say about taking them together
Darunavir and quetiapine
Darunavir's FDA label of August 29, 2025 names quetiapine in its drug interactions section; the quetiapine labels PlainMeds reads (2) do not name darunavir. The darunavir label: “Initiation of PREZISTA with ritonavir in patients taking quetiapine: Consider alternative antiretroviral therapy to avoid increases in quetiapine exposures. …”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the quetiapine FDA label on DailyMed (effective April 10, 2026, H2-Pharma, LLC).
What does the darunavir label say about quetiapine?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: quetiapine; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ quetiapine; Clinical Comment: Initiation of PREZISTA with ritonavir in patients taking quetiapine: Consider alternative antiretroviral therapy to avoid increases in quetiapine exposures. If co-administration is necessary, reduce the quetiapine dose to 1/6 of the current dose and monitor for quetiapine-associated adverse reactions. Refer to the quetiapine prescribing information for recommendations on adverse reaction monitoring. …
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the quetiapine label say about darunavir?
Quetiapine's label (effective April 10, 2026) and its 1 other brand-application label do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SEROQUEL), NDA020639 (Cheplapharm), as published by H2-Pharma, LLC, effective April 10, 2026 (SPL set 8ae62aaf-f8c5-417f-baac-0098369ca322), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Quetiapine | |
|---|---|---|
| Labeled for | HIV | Schizophrenia, Bipolar disorder, Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.127 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once