Flecainide and Carbamazepine Interaction
Drug interaction information between Flecainide and Carbamazepine.
Flecainide and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Flecainide and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine causes the body to break down and remove flecainide faster than normal.
FDA Label Information
Limited data in patients receiving known enzyme inducers ( phenytoin, phenobarbital, carbamazepine ) indicate only a 30% increase in the rate of flecainide elimination.
Flecainide Also Interacts With
- Nirmatrelvir/Ritonavir major
- Darifenacin moderate
- Fluoxetine moderate
- Propranolol minor
- Diltiazem minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Flecainide + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Flecainide's 22. In the minor band specifically: Flecainide has 19 (also Propranolol, Diltiazem, Nifedipine, Digoxin); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Flecainide and Carbamazepine?
Carbamazepine causes the body to break down and remove flecainide faster than normal.
Carbamazepine carries more major-labeled pairs than Flecainide
SPL source-record counts only. This page's band is minor · classes on file: Flecainide (Class IC Antiarrhythmic); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Flecainide's 1. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 19 minor · 22 total
- Other minor peers for Flecainide
- Propranolol
- Diltiazem
- Nifedipine
- Digoxin
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.