Flecainide and Propranolol Interaction
Drug interaction information between Flecainide and Propranolol.
Flecainide and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Flecainide and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs together increases the amount of medicine in your blood and can further weaken the heart's ability to pump.
FDA Label Information
In a study involving healthy subjects receiving flecainide acetate and propranolol concurrently, plasma flecainide levels were increased about 20% and propranolol levels were increased about 30% compared to control values. In this formal interaction study, flecainide acetate and propranolol were each found to have negative inotropic effects; when the drugs were administered together, the effects were additive. The effects of concomitant administration of flecainide acetate and propranolol on the PR interval were less than additive.
Flecainide Also Interacts With
- Nirmatrelvir/Ritonavir major
- Darifenacin moderate
- Fluoxetine moderate
- Diltiazem minor
- Nifedipine minor
Frequently Asked Questions
What SPL severity band is on file for Flecainide + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Flecainide's 22. In the minor band specifically: Flecainide has 19 (also Diltiazem, Nifedipine, Carbamazepine, Digoxin); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Flecainide and Propranolol?
Taking these drugs together increases the amount of medicine in your blood and can further weaken the heart's ability to pump.
Flecainide carries more major-labeled pairs than Propranolol
SPL source-record counts only. This page's band is minor · classes on file: Flecainide (Class IC Antiarrhythmic); Propranolol (Non-Selective Beta-Blocker).
Flecainide has 1 major-labeled pair vs Propranolol's 0. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 19 minor · 22 total
- Other minor peers for Flecainide
- Diltiazem
- Nifedipine
- Carbamazepine
- Digoxin
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.