Flecainide and Nifedipine Interaction
Drug interaction information between Flecainide and Nifedipine.
Flecainide and Nifedipine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Flecainide and Nifedipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There is very little information about how these two drugs work together, so the risks are unknown.
FDA Label Information
There has been too little experience with the coadministration of flecainide acetate with nifedipine or diltiazem to recommend concomitant use.
Flecainide Also Interacts With
- Nirmatrelvir/Ritonavir major
- Darifenacin moderate
- Fluoxetine moderate
- Propranolol minor
- Diltiazem minor
Nifedipine Also Interacts With
- Theophylline major
- Phenytoin moderate
- Nirmatrelvir/Ritonavir moderate
- Tacrolimus Topical moderate
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Flecainide + Nifedipine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nifedipine has 26 labeled pairs on file vs Flecainide's 22. In the minor band specifically: Flecainide has 19 (also Propranolol, Diltiazem, Carbamazepine, Digoxin); Nifedipine has 22 (also Fluoxetine, Fluconazole, Erythromycin, Clarithromycin).
What mechanism field is on file for Flecainide and Nifedipine?
There is very little information about how these two drugs work together, so the risks are unknown.
Nifedipine's labeled portfolio outnumbers Flecainide
SPL source-record counts only. This page's band is minor · classes on file: Flecainide (Class IC Antiarrhythmic); Nifedipine (Calcium Channel Blocker).
1 major · 2 moderate · 19 minor · 22 total
- Other minor peers for Flecainide
- Propranolol
- Diltiazem
- Carbamazepine
- Digoxin
1 major · 3 moderate · 22 minor · 26 total
- Other minor peers for Nifedipine
- Fluoxetine
- Fluconazole
- Erythromycin
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.