What the FDA labels say about taking them together
Digoxin and flecainide
Flecainide's FDA label of June 11, 2026 names digoxin in its warnings section; the digoxin labels PlainMeds reads (3) do not name flecainide. The flecainide label: “Concomitant negative chronotropic therapy such as digoxin or beta-blockers may lower the risk of this complication.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the flecainide FDA label on DailyMed (effective June 11, 2026, Amneal Pharmaceuticals of New York LLC).
What does the digoxin label say about flecainide?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name flecainide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the flecainide label say about digoxin?
Flecainide label, warningsConcomitant negative chronotropic therapy such as digoxin or beta-blockers may lower the risk of this complication.
Source: FDA drug label (Flecainide Acetate), Amneal Pharmaceuticals of New York LLC, effective June 11, 2026 (SPL set ee9595d5-08a1-4529-9215-ddc3c7f929c4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Flecainide | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $0.171 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once