Flecainide and Digoxin Interaction
Drug interaction information between Flecainide and Digoxin.
Flecainide and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Flecainide and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking flecainide can cause the amount of digoxin in your blood to rise slightly.
FDA Label Information
During administration of multiple oral doses of flecainide acetate to healthy subjects stabilized on a maintenance dose of digoxin , a 13% to 19% increase in plasma digoxin levels occurred at six hours postdose.
Flecainide Also Interacts With
- Nirmatrelvir/Ritonavir major
- Darifenacin moderate
- Fluoxetine moderate
- Propranolol minor
- Diltiazem minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Flecainide + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Flecainide's 22. In the minor band specifically: Flecainide has 19 (also Propranolol, Diltiazem, Nifedipine, Carbamazepine); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Flecainide and Digoxin?
Taking flecainide can cause the amount of digoxin in your blood to rise slightly.
Digoxin carries more major-labeled pairs than Flecainide
SPL source-record counts only. This page's band is minor · classes on file: Flecainide (Class IC Antiarrhythmic); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Flecainide's 1. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 19 minor · 22 total
- Other minor peers for Flecainide
- Propranolol
- Diltiazem
- Nifedipine
- Carbamazepine
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.